{"title":"Time Restricted Eating may induce diabetes remission","authors":"Iskandar Idris","doi":"10.1002/doi2.33","DOIUrl":null,"url":null,"abstract":"<p>Intermittent fasting diets, also known as Time Restricted Eating (TRE) have become popular in recent years as an effective weight loss method. TRE is a form of chrono nutrition that focuses on limiting calorie intake to a shortened “eating window”, followed by a prolonged fasting period (e.g. 8 hour feeding window, 16 hour fasting period). Initial time-restricted feeding studies on diet-induced obesity in mice demonstrated improved weight loss and metabolic parameters when eating duration was limited to 8 hours or less. TRE has since been investigated in humans with some evidence for effectiveness in reducing bodyweight and improving certain cardio-metabolic parameters. In this study, researchers conducted a 3-month TRE diet intervention among 36 people with diabetes and found almost 90% of participants, including those who took blood sugar-lowering agents and insulin, reduced their diabetes medication intake after TRE. Fifty-five percent of these people experienced diabetes remission, discontinued their diabetes medication and maintained it for at least one year. Importantly, sixty-five percent of the study participants who achieved diabetes remission had a diabetes duration of more than 6 years – disease duration >6 years was an exclusion criteria in the DIRECT study which reported diabetes remission following a Very Low calorie Diet programme. Overall this study provided preliminary evidence of efficacy of TRE for diabetes remission. It would be interesting to have a randomised controlled study of VLCD vs TRE with a primary outcome measure being rate of diabetes remission.</p><p>The study was published in the Endocrine Reviews and received funding from the National Natural Science Foundation of China.</p>","PeriodicalId":100370,"journal":{"name":"Diabetes, Obesity and Metabolism Now","volume":"1 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/doi2.33","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Obesity and Metabolism Now","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/doi2.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Intermittent fasting diets, also known as Time Restricted Eating (TRE) have become popular in recent years as an effective weight loss method. TRE is a form of chrono nutrition that focuses on limiting calorie intake to a shortened “eating window”, followed by a prolonged fasting period (e.g. 8 hour feeding window, 16 hour fasting period). Initial time-restricted feeding studies on diet-induced obesity in mice demonstrated improved weight loss and metabolic parameters when eating duration was limited to 8 hours or less. TRE has since been investigated in humans with some evidence for effectiveness in reducing bodyweight and improving certain cardio-metabolic parameters. In this study, researchers conducted a 3-month TRE diet intervention among 36 people with diabetes and found almost 90% of participants, including those who took blood sugar-lowering agents and insulin, reduced their diabetes medication intake after TRE. Fifty-five percent of these people experienced diabetes remission, discontinued their diabetes medication and maintained it for at least one year. Importantly, sixty-five percent of the study participants who achieved diabetes remission had a diabetes duration of more than 6 years – disease duration >6 years was an exclusion criteria in the DIRECT study which reported diabetes remission following a Very Low calorie Diet programme. Overall this study provided preliminary evidence of efficacy of TRE for diabetes remission. It would be interesting to have a randomised controlled study of VLCD vs TRE with a primary outcome measure being rate of diabetes remission.
The study was published in the Endocrine Reviews and received funding from the National Natural Science Foundation of China.