Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy.

IF 3.6 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY RNA Biology Pub Date : 2023-01-01 Epub Date: 2023-10-26 DOI:10.1080/15476286.2023.2272118

Wei Wang, Lei Sun, Meng-Ting Huang, Yun Quan, Tao Jiang, Zhichao Miao, Qiong Zhang

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Abstract

Circular RNA (circRNA) forms closed loops via back-splicing in precursor mRNA, resisting exonuclease degradation. In higher eukaryotes, protein-coding genes create circRNAs through exon back-splicing. Unlike mRNAs, circRNAs possess unique production and structural traits, bestowing distinct cellular functions and biomedical potential. In this review, we explore the pivotal roles of viral circRNAs and associated RNA in various biological processes. Analysing the interactions between viral circRNA and host cellular machinery yields fresh insights into antiviral immunity, catalysing the development of potential therapeutics. Furthermore, circRNAs serve as enduring biomarkers in viral diseases due to their stable translation within specific tissues. Additionally, a deeper understanding of translational circRNA could expedite the establishment of circRNA-based expression platforms, meeting the rising demand for broad-spectrum viral vaccines. We also highlight the applications of circular RNA in biomarker studies as well as circRNA-based therapeutics. Prospectively, we expect a technological revolution in combating viral infections using circRNA.

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病毒性疾病中的调节性环状RNA：在诊断和治疗中的应用。

环状RNA（circRNA）通过前体mRNA的反向剪接形成闭环，抵抗核酸外切酶降解。在高等真核生物中，蛋白质编码基因通过外显子反向剪接产生circRNA。与信使核糖核酸不同，circRNA具有独特的生产和结构特征，赋予其独特的细胞功能和生物医学潜力。在这篇综述中，我们探讨了病毒circRNA和相关RNA在各种生物过程中的关键作用。分析病毒circRNA和宿主细胞机制之间的相互作用，可以对抗病毒免疫产生新的见解，促进潜在治疗方法的开发。此外，circRNA由于其在特定组织内的稳定翻译，在病毒性疾病中起着持久的生物标志物作用。此外，对翻译circRNA的深入了解可以加快建立基于circRNA表达平台，满足对广谱病毒疫苗日益增长的需求。我们还强调了环状RNA在生物标志物研究以及基于环状RNA的治疗中的应用。展望未来，我们期待使用circRNA对抗病毒感染的技术革命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

RNA Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy