An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile.

Plant signaling & behavior Pub Date : 2023-12-31 Epub Date: 2023-10-25 DOI:10.1080/15592324.2023.2271799
Emilia R Gutiérrez-Mireles, José Carlos Páez-Franco, Raúl Rodríguez-Ruíz, Juan Manuel Germán-Acacio, M Casandra López-Aquino, Manuel Gutiérrez-Aguilar
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Abstract

Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In Arabidopsis thaliana, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.

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缺乏线粒体钙转运调节因子MICU的拟南芥突变体系显示出改变的代谢产物谱。
植物代谢不断变化,需要输入信号进行有效调节。线粒体钙单转运蛋白(MCU)耦合器质和细胞质钙振荡,导致大量物种的氧化代谢调节。在拟南芥中,AtMICU的基因缺失导致线粒体钙处理和超微结构的改变。在此,我们旨在进一步评估AtMICU基因缺失的后果。我们的研究结果证实,AtMICU保护与碳水化合物、氨基酸和植物醇代谢修饰相关的细胞内钙转运。讨论了这些改动的含义。
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