Molecularly imprinted graphene based biosensor as effective tool for electrochemical sensing of uric acid

Sensors International Pub Date : 2023-01-01 DOI:10.1016/j.sintl.2023.100243

Gowri Soman , Vandana M , Gurumurthy Hegde

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引用次数: 2

Abstract

Graphene oxide based molecularly imprinted polymer was designed by incorporating vinyltrimethoxysilane into the layers of graphene oxide, which was copolymerized with functional monomers such as Itaconic acid (IA) and methyl methacrylate (MMA) was developed via bulk imprinting technique. The prepared polymer was studied for selective sensing the uric acid (UA) in blood serum. The electrode was constructed by modifying bare glassy carbon electrodes with the prepared molecularly imprinted polymer (MIP) via drop cast method. Electrochemical measurements were made by Cyclic voltammetric (CV) and Differential Pulse Voltammetric (DPV) response of the sensor. The physical and chemical properties of the resultant material will be characterized by FTIR spectroscopy, XRD and FESEM. The constructed sensor showed a regression coefficient (R²) of 0.9302 with limit of detection (LOD) of about 0.565 μM. The developed sensor is reusable without any compromise in its selectivity. All the results confirm that the constructed biosensor requires no pre-treatment of samples and is suitable for real sample analysis.

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分子印迹石墨烯基生物传感器作为尿酸电化学传感的有效工具

将乙烯基三甲氧基硅烷引入氧化石墨烯层中，与衣康酸（IA）、甲基丙烯酸甲酯（MMA）等功能单体共聚，设计了氧化石墨烯分子印迹聚合物。研究了所制备的聚合物对血清尿酸（UA）的选择性传感。用制备的分子印迹聚合物（MIP）通过滴注法对裸玻碳电极进行改性，构建了电极。采用循环伏安法（CV）和微分脉冲伏安法（DPV）对传感器进行了电化学测量。所得材料的物理和化学性质将通过FTIR光谱、XRD和FESEM进行表征。所构建的传感器显示出0.9302的回归系数（R2），检测限（LOD）约为0.565μM。所开发的传感器是可重复使用的，在选择性方面没有任何妥协。所有结果证实，所构建的生物传感器不需要对样品进行预处理，并且适合于真实样品分析。

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来源期刊

Sensors International

CiteScore

17.40

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0.00%

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