Optoplasmonic biosensor for lung cancer telediagnosis: Design and simulation analysis

Sensors International Pub Date : 2023-01-01 DOI:10.1016/j.sintl.2023.100232

Alemayehu Getahun Kumela, Abebe Belay Gemta, Alemu Kebede Hordofa, Tamirat Abebe Desta, Mulubirhan Dangish, Habtamu Dagnew Mekonnen

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引用次数: 2

Abstract

Applying quantum technology to dispatch face-to-face medical activities has generated significant interest. Unfortunately, the work on remote medical treatment soliciting quantum medication and information processing techniques is hard to observe. In this research, we proposed the Mach–Zehnder interferometer (MZI) based optoplasmonic biosensors (OPBs) with two homodyne detectors for remote-based lung cancer detection using classical and quantum mechanical principles. From the classical basis (Drude-Lorentz model and Kretschmann configuration), the influence of silver nanoparticles (Ag NPs) layers and biomolecule concentration on the performance of biosensors has been investigated. The different types of cancer cells for CL1-5, A549, and HT-29 have been used to analyze the sensitivity, and 319, 332, and 365 (deg/RIU) have been achieved, respectively. In addition, from quantum mechanical principles, the biosignals were conveyed through quantum teleportation in the form of the quantum state of light via fiber optics cable to enable precise remote detection of lung cancer. The obtained sensitivity and teleportation fidelity clearly reveal, the best candidacy of the proposed optoplasmonic biosensor for lung cancer telediagnosis.

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用于癌症远程诊断的光等离子体生物传感器的设计与仿真分析

将量子技术应用于面对面的医疗活动已经引起了人们的极大兴趣。不幸的是，在远程医疗方面寻求量子药物和信息处理技术的工作很难观察到。在这项研究中，我们提出了基于马赫-曾德尔干涉仪（MZI）的光等离子体生物传感器（OPB），该传感器具有两个零差检测器，用于使用经典和量子力学原理进行基于远程的癌症检测。从经典基础（Drude-Lorentz模型和Kretschmann构型）出发，研究了银纳米粒子（Ag-NPs）层和生物分子浓度对生物传感器性能的影响。已使用CL1-5、A549和HT-29的不同类型的癌症细胞来分析敏感性，并分别获得319、332和365（deg/RIU）。此外，从量子力学原理来看，生物信号是通过光纤电缆以光的量子态的形式通过量子隐形传态传输的，以实现对癌症的精确远程检测。获得的灵敏度和隐形传态保真度清楚地揭示了所提出的用于癌症远程诊断的光等离子体生物传感器的最佳候选。

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来源期刊

Sensors International

CiteScore

17.40

自引率

0.00%

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