Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2. What have we learned?

IF 1.6 Q4 INFECTIOUS DISEASES Journal of clinical virology plus Pub Date : 2023-10-05 DOI:10.1016/j.jcvp.2023.100166
Marina Mozgovoj , Merceder Dieder Graham , Cecilia Ferrufino , Sofia Blanc , Adriana Fernandez Souto , Marcela Pilloff , Maria Jose Dus Santos
{"title":"Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2. What have we learned?","authors":"Marina Mozgovoj ,&nbsp;Merceder Dieder Graham ,&nbsp;Cecilia Ferrufino ,&nbsp;Sofia Blanc ,&nbsp;Adriana Fernandez Souto ,&nbsp;Marcela Pilloff ,&nbsp;Maria Jose Dus Santos","doi":"10.1016/j.jcvp.2023.100166","DOIUrl":null,"url":null,"abstract":"<div><p>Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.</p><p>Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.</p><p>Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.</p><p>The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.</p><p>Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.</p><p>Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.</p></div>","PeriodicalId":73673,"journal":{"name":"Journal of clinical virology plus","volume":"3 4","pages":"Article 100166"},"PeriodicalIF":1.6000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical virology plus","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667038023000339","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.

Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.

Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.

The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.

Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.

Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
严重急性呼吸系统综合征冠状病毒2型有症状和无症状感染者的病毒载量。我们学到了什么?
在新冠肺炎大流行期间,无症状和症状前患者在维持和传播感染方面发挥了关键作用。然而,关于无症状患者的传染性,人们提出了相互矛盾的观点。无症状病例的识别依赖于严重急性呼吸系统综合征冠状病毒2型的基因组检测,并且在缺乏常见流行病学变量的情况下,病毒载量(VL)的量化已被提议作为严重急性呼吸系冠状病毒2型传播的估计器。根据研究人群、实验设计和采样等变量,对有症状和无症状患者的VL进行比较显示出不同的结果。这项工作的目的是确定采样时有症状和无症状患者的VL,并回顾性地确定它们与疾病严重程度和影响新冠肺炎进程的其他参数的关系,这两个城镇位于布宜诺斯艾利斯,阿根廷。我们的研究结果表明,在全球范围内分析有症状和无症状患者的VL有显著差异。此外,当分析每个新冠肺炎波的VL时,发现了显著差异。在第一波中,无症状患者的VL(log10 8,21 gc/µl)显著高于有症状患者(log10 6,51 gc/µl),而;在第二波中,无症状患者的VLs显著低于有症状患者(分别为log10 4,51 gc/µl和log10 5,23 gc/µl)。在第三波中,两种类型患者的VL之间没有观察到显著差异。这项工作的结果表明,对有症状和无症状患者的筛查对于减少严重急性呼吸系统综合征冠状病毒2型向社区的传播至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of clinical virology plus
Journal of clinical virology plus Infectious Diseases
CiteScore
2.20
自引率
0.00%
发文量
0
审稿时长
66 days
期刊最新文献
Performance evaluation of the Qiagen BK virus ASR on the NeuMoDx system Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia A prospective study to evaluate the clinical specificity of the cobas® MPX test kit for screening for HIV RNA, HCV RNA, and HBV DNA in blood donation samples using the cobas® 6800 system in HBV endemic areas A rapid review of the epidemiology and combating strategies of hepatitis C virus infection in Ghana Serologic evidence of dengue and chikungunya among patients with acute febrile illness in Ghana, 2016 – 2018
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1