A compound Schiff base coating on biomedical magnesium alloy for enhanced corrosion resistance and biocompatibility

Smart Materials in Manufacturing Pub Date : 2023-01-01 DOI:10.1016/j.smmf.2022.100003

Yulong Sheng , Weijie Li , Yaru Chai , Sihan Yin , Jingan Li , Shaokang Guan

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引用次数: 5

Abstract

The rapid degradation and delayed endothelialization of magnesium (Mg) alloys are the bottlenecks that limit their application in the direction of cardiovascular stents. In the previous work, we have reported a novel compound coating composed of three newly synthesized Schiff bases which significantly improved the corrosion resistance of the Mg alloy. However, the effect of electrostatic spraying time on the physicochemical properties, corrosion resistance and biocompatibility of the compound coating has not been systematically explored. In the present study, the compound Schiff base coating was electrostatic-sprayed on to the Mg alloy surface with 1.0 min (CP-1.0), 1.5 min (CP-1.5), 2.0 min (CP-2.0) and 2.5 min (CP-2.5), respectively. Our data suggested that CP-1.5 possessed more homogeneous surface, better corrosion resistance, stronger hemocompatibility and pro-endothelialization ability. Our study may give inspiration for designing the special coatings only for the biodegradable Mg alloy stents for vascular application.

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生物镁合金表面复合席夫碱涂层增强耐腐蚀性和生物相容性

镁合金的快速降解和延迟内皮化是限制其在心血管支架领域应用的瓶颈。在以前的工作中，我们报道了一种由三种新合成的席夫碱组成的新型复合涂层，它显著提高了镁合金的耐腐蚀性。然而，静电喷涂时间对复合涂层理化性能、耐腐蚀性和生物相容性的影响尚未得到系统的研究。在本研究中，以1.0最小值（CP-1.0），1.5最小值（CP-1.5），2.0最小值（CP-2.0）和2.5min（CP-2.5）。我们的数据表明，CP-1.5具有更均匀的表面、更好的耐腐蚀性、更强的血液相容性和促内皮化能力。我们的研究可能为设计仅用于可生物降解镁合金支架的特殊涂层提供启示。

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Smart Materials in Manufacturing

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