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Physico-mechanical evaluation of benzoyl peroxide-treated water hyacinth reinforced polyvinyl alcohol composites and DFT studies of the reaction of the monomer of cellulose 过氧化苯甲酰处理水葫芦增强聚乙烯醇复合材料的物理力学性能评价及纤维素单体反应的DFT研究
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2025.100123
Kaniz Fatema , Taslima Akter , Shabiba Parvin Shandhi , Md Khabir Uddin Sarkar , Mohammad Amirul Hoque , Mohammad Shahriar Bashar , Shahin Sultana
The growing interest in natural fiber-reinforced polymer composites is driven by their sustainability and enhanced mechanical properties. In Bangladesh, the unchecked proliferation of water hyacinth has become a significant environmental issue, altering the pH and salinity of aquatic ecosystems. This study explores the potential of untreated and chemically treated water hyacinth fibers as reinforcement in polyvinyl alcohol (PVA) composites. The untreated water hyacinth (UWH) was subjected to alkali treatment to produce mercerized water hyacinth (MWH), then oxidation to produce oxidized water hyacinth (OWH). The structural modifications of UWH, MWH, and OWH were confirmed through ATR-FTIR spectroscopy. Composites were fabricated by embedding UWH and OWH fibers into PVA at varying concentrations (0.50, 1.00, 2.5, and 5.0 wt%) via compression molding. Composites with 1 % OWH exhibited the best performance, showing a 127 % increase in tensile strength, 162 % increase in elongation, and 28 % reduction in water absorption compared to UWH-PVA and pure PVA. The improved performance of OWH-PVA composites is attributed to enhanced fiber–matrix adhesion. Thermogravimetric analysis confirmed thermal stability, and Density Functional Theory (DFT) calculations supported the chemical modifications observed experimentally. These results highlight the potential of water hyacinth fibers as a sustainable reinforcement material for PVA-based composites.
对天然纤维增强聚合物复合材料日益增长的兴趣是由其可持续性和增强的机械性能驱动的。在孟加拉国,水葫芦的无限制繁殖已经成为一个重大的环境问题,改变了水生生态系统的pH值和盐度。本研究探讨了未经处理和化学处理的水葫芦纤维作为聚乙烯醇(PVA)复合材料增强材料的潜力。对未经处理的水葫芦(UWH)进行碱处理,得到丝光水葫芦(MWH),然后氧化得到氧化水葫芦(OWH)。通过ATR-FTIR光谱分析证实了UWH、MWH和OWH的结构修饰。通过压缩成型将UWH和OWH纤维以不同的浓度(0.50、1.00、2.5和5.0 wt%)嵌入PVA中制备复合材料。与UWH-PVA和纯PVA相比,添加1% OWH的复合材料性能最佳,抗拉强度提高127%,伸长率提高162%,吸水率降低28%。OWH-PVA复合材料性能的提高是由于增强了纤维-基质的附着力。热重分析证实了热稳定性,密度泛函理论(DFT)计算支持实验观察到的化学修饰。这些结果突出了水葫芦纤维作为聚乙烯醇基复合材料可持续增强材料的潜力。
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引用次数: 0
Nonplanar rotary 3D printing framework for sustainable thin-walled structures manufacturing 用于可持续薄壁结构制造的非平面旋转3D打印框架
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2026.100125
Hesam Soleimanzadeh, Moslem Mohammadi, Bernard Rolfe, Ali Zolfagharian
Rotary 3D printing offers an effective approach for fabricating cylindrical and curved-surface geometries without conventional supports, yet existing rotary slicing strategies remain unstandardized and difficult to reproduce across diverse platforms. This work introduces a unified, open-source rotary 3D printing framework integrating three complementary slicing pipelines, ranging from CAD-driven visual scripting to a fully automated Python–based user interface workflow. The framework incorporates a volume-preserving unwrapping formulation and a calibrated flow-ratio compensation factor that significantly improves extrusion continuity and seam-line closure. Multi-material dissolvable raft support strategies are implemented to enhance mandrel tolerance control, adhesion tuning, and sustainable detachment. The framework is validated through comprehensive quantitative experiments. Optical 3D metrology and roughness measurements demonstrate uniform radial and circumferential surface quality across cylindrical and auxetic structures. Annular-ring tests verify the effectiveness of correction in eliminating seam gaps. Scanning electron microscopy and optical cross-section imaging confirm interlayer fidelity and void-free dual-material bonding. Comparative studies further show notable reductions in material consumption and energy usage relative to planar printing with dense supports. Demonstrations across auxetic lattices, re-entrant structures, chiral shells, spiral geometries, and thin-walled cylinders highlight the robustness and versatility of the approach. Overall, this work establishes a general-purpose and open-source rotary manufacturing framework compatible with commercial 3D printers and suitable for programmable and 4D printing applications.
旋转3D打印为在没有传统支撑的情况下制造圆柱形和曲面几何形状提供了有效的方法,但现有的旋转切片策略仍然不标准化,难以在不同的平台上复制。这项工作引入了一个统一的、开源的旋转3D打印框架,集成了三个互补的切片管道,从cad驱动的可视化脚本到完全自动化的基于python的用户界面工作流。该框架结合了保持体积的解包裹配方和校准的流量比补偿因子,显着提高了挤压连续性和缝线封闭性。采用多材料可溶筏支撑策略,增强芯棒公差控制、粘附调节和可持续分离。通过全面的定量实验对该框架进行了验证。光学三维测量和粗糙度测量证明了均匀的径向和周向表面质量跨越圆柱形和异形结构。环环试验验证了修正在消除缝隙方面的有效性。扫描电镜和光学截面成像证实层间保真度和无空隙双材料键合。比较研究进一步表明,与密集支撑的平面印刷相比,材料消耗和能源使用显著减少。通过对辅助晶格、可重入结构、手性壳、螺旋几何和薄壁圆柱体的演示,突出了该方法的健壮性和多功能性。总的来说,这项工作建立了一个通用的和开源的旋转制造框架与商业3D打印机兼容,适用于可编程和4D打印应用。
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引用次数: 0
OpenTM: An open-source, single-GPU, large-scale thermal microstructure design framework OpenTM:开源、单gpu、大规模热微结构设计框架
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2025.100118
Yuchen Quan , Xiaoya Zhai , Xiao-Ming Fu
Thermal microstructures are engineered to manipulate heat flow. We present OpenTM, an open-source GPU-based framework for designing periodic 3D high-resolution thermal microstructures via inverse optimization of target conductivity. To ensure numerical stability without incurring large memory overheads, we employ an adaptive volume-fraction strategy within the Optimality Criteria (OC) method. Practical demonstrations at a resolution of 512×512×512 achieve runtimes under 12 s per iteration on an NVIDIA Tesla P40 GPU, with a peak memory footprint of 10.78 GB. Our open-source, high-performance implementation is publicly available at https://github.com/quanyuchen2000/OPENTM and is easily installed via Anaconda. A Python interface ensures accessibility for non-C/C++ users. This work highlights the potential of OpenTM as a powerful tool for the rapid structural optimization of thermal microstructures, fostering deeper exploration of their exotic heat-management capabilities.
热微结构是用来控制热流的。我们提出了OpenTM,一个基于开源gpu的框架,用于通过目标电导率的逆优化来设计周期性3D高分辨率热微结构。为了确保数值稳定性而不产生大量内存开销,我们在最优性标准(OC)方法中采用了自适应体积分数策略。在分辨率为512×512×512的实际演示中,NVIDIA Tesla P40 GPU每次迭代的运行时间低于12秒,峰值内存占用为10.78 GB。我们的开源、高性能实现可以在https://github.com/quanyuchen2000/OPENTM上公开获得,并且可以通过Anaconda轻松安装。Python接口确保了非C/ c++用户的可访问性。这项工作突出了OpenTM作为热微结构快速结构优化的强大工具的潜力,促进了对其奇异热管理能力的更深入探索。
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引用次数: 0
Achieving excellent dispersion properties, interfacial strengthening and substantial biofunctionality in biodegradable HA@GO/Zn matrix composites via the combination of hetero-agglomeration method and in situ growth strategy 通过异质团聚法和原位生长策略的结合,获得了可生物降解HA@GO/Zn基复合材料优异的分散性能、界面强化和丰富的生物功能
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2025.100119
Zixuan Li , Yingjian Lin , Xiao Wang , Wei Li , Hao Han , Wei Gao , Chunyong Liang , Xiaohao Sun , Debao Liu
Nowadays, biodegradable zinc (Zn) matrix composites attracted extensive attention due to their moderate degradation period, good biocompatibility and substantial biofunctionality. Nevertheless, poor dispersion properties and poor interfacial strength deteriorate the comprehensive performance of the Zn matrix biocomposites. Herein, a novel approach, namely the combination of hetero-agglomeration method and in situ growth strategy (CHMGS), was developed to simultaneously ameliorate the dispersion and interfacial properties in biodegradable Zn-based composites. The CHMGS process utilizes GO as an “bridge” to connect the bioactive reinforcement with the Zn matrix. In other word, based on the principle of electrostatic neutralization, GO “bridge” was uniformly dispersed into the Zn powder. Then, bioactive hydroxyapatite (HA) uniformly and firmly decorated on the GO “bridge” via a in situ solvothermal reaction. Eventually, uniform dispersion of HA and enhancing the interfacial strength was achieved in HA@GO/Zn biocomposites after spark plasma sintering (SPS). As a result, after the introduction of HA@GO, the yield strength (YS) increased by up to 16.1 %, and the uniaxial compressive strength (UCS) increased by 22.1 %. The potential difference between HA and matrix elevates the degradation rate (0.221 mm y−1 for [email protected]/Zn) and promotes Ca-P deposition. In vitro, 25 % and 50 % extracts from the composites show no cytotoxicity to MC3T3-E1 cells. Transcriptomics reveal the composites promote mineral absorption and osteoblast differentiation by upregulating genes (Mt, Prkcg, Lox, etc.), accelerating bone regeneration. Above all, [email protected]/Zn biocomposites possessing excellent dispersion properties, improved mechanical performance, up-regulated degradation rate and multiple biofunctionality should be useful for biomedical applications.
目前,可生物降解锌基复合材料因其降解周期适中、生物相容性好、生物功能丰富而受到广泛关注。然而,较差的分散性能和较差的界面强度使锌基生物复合材料的综合性能下降。本文提出了一种异质团聚法与原位生长策略(CHMGS)相结合的新方法,以同时改善可生物降解锌基复合材料的分散和界面性能。CHMGS工艺利用氧化石墨烯作为连接生物活性增强物与锌基质的“桥梁”。即基于静电中和原理,将氧化石墨烯“桥”均匀分散到锌粉中。然后,生物活性羟基磷灰石(HA)通过原位溶剂热反应均匀而牢固地修饰在氧化石墨烯“桥”上。最终,通过放电等离子烧结(SPS),在HA@GO/Zn生物复合材料中实现了HA的均匀分散和界面强度的提高。结果表明,引入HA@GO后,屈服强度(YS)提高16.1%,单轴抗压强度(UCS)提高22.1%。HA和基质之间的电位差提高了降解速率([email protected]/Zn为0.221 mm y - 1),促进了Ca-P的沉积。在体外,复合材料25%和50%的提取物对MC3T3-E1细胞无细胞毒性。转录组学显示复合材料通过上调基因(Mt, Prkcg, Lox等)促进矿物质吸收和成骨细胞分化,加速骨再生。总之,[email protected]/Zn生物复合材料具有优异的分散性能、改善的机械性能、上调的降解率和多种生物功能,应该对生物医学应用有用。
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引用次数: 0
Laser powder bed fusion of biodegradable metallic implants: current status, challenges, and future perspectives 激光粉末床融合生物可降解金属植入物:现状、挑战和未来展望
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2025.100122
Fang Deng , Hao Li , Xiwen He , Hejin Yang , Guihua Wu , Yinjin Shao , Xuehua Wu
Biodegradable metals (BMs), encompassing magnesium (Mg)-, zinc (Zn)-, and iron (Fe)-based alloys, represent a revolutionary advancement in biomedical implants. Among them, Mg-based alloys are distinguished by their bone-mimetic elastic modulus, which helps mitigate stress shielding, and their bioactive Mg2+ ions that promote osteogenesis. Zn-based alloys provide an intermediate degradation rate, avoiding the rapid corrosion of Mg and the prolonged presence of Fe, while Fe-based alloys are valued for their superior mechanical strength, making them suitable for load-bearing applications. These materials eliminate the need for secondary removal surgeries, minimize stress shielding, and support tissue regeneration. However, conventional manufacturing methods struggle to produce patient-specific implants with complex geometries. Additive manufacturing (AM), particularly laser powder bed fusion (LPBF), enables the fabrication of customized, porous implants with high dimensional accuracy and refined microstructures. The rapid cooling inherent to LPBF enhances mechanical strength, corrosion resistance, and degradation control. Nevertheless, key challenges remain, such as optimizing process parameters to minimize defects, ensuring consistent degradation behavior, and matching mechanical performance with tissue healing timelines. This review systematically outlines recent advances in the AM-fabricated BMs, covering material development, powder preparation, parameter optimization, post-processing, and defect mitigation. It critically assesses their mechanical properties, degradation behavior, and biocompatibility. Finally, the review highlights persistent challenges and suggests future research directions to advance clinical applications.
生物可降解金属(BMs),包括镁(Mg)-,锌(Zn)-和铁(Fe)基合金,代表了生物医学植入物的革命性进步。其中,镁基合金的特点是其模拟骨的弹性模量,有助于减轻应力屏蔽,以及其促进成骨的生物活性Mg2+离子。锌基合金提供了一个中等的降解率,避免了Mg的快速腐蚀和Fe的长时间存在,而铁基合金因其优越的机械强度而受到重视,使其适用于承载应用。这些材料消除了二次切除手术的需要,减少了应力屏蔽,并支持组织再生。然而,传统的制造方法很难生产出具有复杂几何形状的患者特异性植入物。增材制造(AM),特别是激光粉末床融合(LPBF),能够制造具有高尺寸精度和精细微观结构的定制多孔植入物。快速冷却固有的LPBF提高机械强度,耐腐蚀性和降解控制。然而,关键的挑战仍然存在,例如优化工艺参数以最大限度地减少缺陷,确保一致的降解行为,以及将机械性能与组织愈合时间表相匹配。这篇综述系统地概述了am制造BMs的最新进展,包括材料开发、粉末制备、参数优化、后处理和缺陷缓解。它批判性地评估了它们的机械性能,降解行为和生物相容性。最后,综述强调了持续存在的挑战,并提出了未来的研究方向,以推进临床应用。
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引用次数: 0
Synergistic improvement of strength and elongation in laser-melting-deposited 18Ni300/316 heterostructured dual-phase steel by heat treatment 热处理对激光熔敷18Ni300/316异质组织双相钢强度和伸长率的协同提高
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2026.100124
Tong Yang , Haoye Zeng , Zhen Liu , Pinghu Chen , Chao Yang , Changjun Qiu , Paul K. Chu
18Ni300 maraging steel has an ultra-high strength above 2000 MPa after aging, but the elongation is compromised. Herein, a heterogeneous lamellar structure and solution-aging heat treatment are designed to overcome the trade-off between strength and elongation. Laser melting deposition using a synchronous feeder is employed to fabricate the heterostructured materials (HSM), and the powder delivery rates are optimized to prepare high-quality materials. The ultimate tensile strength and total elongation of the 18Ni300 maraging steel are improved to 1051 MPa and 10.4 %, respectively. The hetero-structure composed of a sandwiched layer of the 316L soft phase in the 18Ni300 hard phase exhibits high strength and elongation due to hetero-deformation-induced (HDI) strengthening, which obtain the trade-off between strength (reduction of 6.7 %) and elongation (increase of 62.3 %) when the austenitic layer thickness is optimized. Solution-aging treatment is performed to adjust the microstructure, including Ni-(Mo, Ti) nano-precipitates, second-phase diffusion, and refined grains relative to as-fabricated sample. The excellent tensile characteristics stem collectively from a synergistic strengthening effect of HDI strengthening, nanoscale precipitation, refined grains, grain boundaries, and dislocations. The HSM have the advantage of restraining sudden fracture, and the results reveal an innovative strategy to improve the properties of bearings and engineering materials.
18Ni300马氏体时效钢时效后具有2000 MPa以上的超高强度,但伸长率较低。在此,设计了非均相片层结构和固溶时效热处理来克服强度和伸长率之间的权衡。采用同步给料机激光熔化沉积制备异质结构材料,优化出粉率,制备出高质量的材料。18Ni300马氏体时效钢的极限抗拉强度和总伸长率分别提高到1051 MPa和10.4%。由316L软相夹在18Ni300硬相中形成的异质组织由于异质变形诱导(HDI)强化而具有较高的强度和伸长率,当奥氏体层厚度优化时,获得了强度(降低6.7%)和伸长率(提高62.3%)的平衡。通过固溶时效处理来调整微观结构,包括Ni-(Mo, Ti)纳米析出物、第二相扩散和相对于制备样品的细化晶粒。优异的拉伸性能源于HDI强化、纳米级析出、细化晶粒、晶界和位错的协同强化效应。高速切削加工具有抑制突然断裂的优点,为提高轴承和工程材料的性能提供了一种创新的策略。
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引用次数: 0
Enhancing corrosion resistance of additively manufactured magnesium alloys via in-situ reaction-driven dual mechanisms 原位反应驱动双机制增强增材镁合金耐腐蚀性能
Pub Date : 2026-01-01 DOI: 10.1016/j.smmf.2025.100097
Wenjing Yang , Quanyi Tong , Guochao Wu , Youwen Yang , Fang Deng , Xiong Shuai , Chongxian He , Cijun Shuai
Mg and its alloys hold significant promise as biomedical materials, but their orthopedic applications are limited by inadequate corrosion resistance. This study proposed a dual-effect corrosion inhibition strategy mediated by in-situ reaction. Specifically, CaO nanoparticles were incorporated into ZK60 via laser powder bed fusion to function as reactive peritectic, reacting with the Mg melt to form MgO and Mg2Ca phases. Upon degradation initiation, MgO undergoes rapid hydrolysis to generate a protective Mg(OH)2 layer that provides immediate barrier protection. Concurrently, the Mg2Ca phases act as sacrificial anode within galvanic couples relative to the α-matrix grains. These phases preferentially degrade to deliver cathodic protection to Mg grains while producing Ca-enriched products that densify the corrosion layer, thereby retarding overall degradation. Volta potential measurements confirmed the sacrificial anode function of Mg2Ca, exhibiting approximately 130 mV more negative potential than the α-Mg matrix. Electrochemical testing demonstrated that CaO incorporation significantly enhanced the corrosion resistance of ZK60 alloy throughout both initial and prolonged exposure periods. Mott-Schottky analysis revealed that the ZK60-CaO displayed characteristic n-type semiconductor behavior with reduced carrier concentration (approximately 1.29 × 1022 cm−3) than ZK60 alloy, indicative of a denser, more protective corrosion product film versus ZK60. After immersion for 24 h, the corrosion rate of ZK60-CaO alloy was decreased from 1.54 mm/y to 0.35 mm/y, confirming that the CaO-formed passive layer effectively retarded the alloy degradation. This synergistic dual-effect strategy offers a promising approach to improve corrosion resistance and extend the functional lifespan of Mg-based implants.
镁及其合金作为生物医学材料具有重要的前景,但它们的矫形应用受到耐腐蚀性不足的限制。本研究提出了原位反应介导的双效缓蚀策略。具体来说,CaO纳米颗粒通过激光粉末床熔合加入到ZK60中,作为反应包晶,与Mg熔体反应形成MgO和Mg2Ca相。在降解开始后,MgO经过快速水解产生保护性的Mg(OH)2层,提供即时的屏障保护。同时,相对于α-基体晶粒,Mg2Ca相在电偶中充当牺牲阳极。这些相优先降解,为Mg晶粒提供阴极保护,同时产生富钙产物,使腐蚀层致密,从而延缓整体降解。伏特电位测量证实了Mg2Ca的牺牲阳极功能,其负电位比α-Mg基体高出约130 mV。电化学测试表明,CaO的掺入显著提高了ZK60合金的耐蚀性,无论是在初始暴露期还是延长暴露期。Mott-Schottky分析表明,ZK60- cao表现出典型的n型半导体行为,载流子浓度比ZK60合金低(约1.29 × 1022 cm−3),表明与ZK60合金相比,ZK60合金具有更致密、更具保护性的腐蚀产物膜。浸泡24 h后,ZK60-CaO合金的腐蚀速率从1.54 mm/y降低到0.35 mm/y,证实cao形成的钝化层有效延缓了合金的降解。这种协同的双重效应策略为提高镁基植入物的耐腐蚀性和延长其功能寿命提供了一种有前途的方法。
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引用次数: 0
Additive manufacturing of functional high-performance polymers for energy storage, conversion, and insulation systems 用于能量储存、转换和绝缘系统的功能性高性能聚合物的增材制造
Pub Date : 2025-12-06 DOI: 10.1016/j.smmf.2025.100121
Long Chanraksmey , Bingying Nie , Wei Zhao , Kunyapat Thummavichai , Yu Chen , Binling Chen
Energy-related systems require materials that not only withstand harsh operating conditions, including extreme temperatures, corrosive environments, mechanical stresses, and radiation, but also can be manufactured into complex geometries (e.g. porous networks, patterned membranes, and architected 3D lattices etc.) and integrated structures to deliver specific functionalities such as insulation, separation, membrane operation, energy storage, or shielding. Traditional methods like molding and machining often struggle to create intricate multifunctional components such as porous scaffolds, interdigitated electrodes and layered membranes. In contrast, advances in additive manufacturing (AM) have transformed the production of energy-related components by enabling greater design freedom, rapid prototyping, and the fabrication of customized, high-performance parts with reduced material waste. Among the different classes of AM, high-performance polymers (HPPs) have emerged as promising candidates due to their outstanding thermal, mechanical, and chemical resilience. These, including Polyamide (PA), Polyetherimide (PEI), Polyphenylene Sulfide (PPS), Polysulfone (PSU), Polyetheretherketone (PEEK), and Polyimide (PI), are particularly suited for AM in demanding energy applications. This review summarizes recent advances in the AM of HPPs for electrochemical and thermal energy storage, hydrogen production and storage, oil and gas systems, and radiation shielding. It also examines how structural design and composite reinforcement enhance performance, and outlines current challenges and future research directions to advance AM technologies for energy-related applications.
能源相关系统需要的材料不仅能够承受恶劣的操作条件,包括极端温度、腐蚀性环境、机械应力和辐射,而且还可以制造成复杂的几何形状(例如多孔网络、图案膜和架构3D晶格等)和集成结构,以提供特定的功能,如绝缘、分离、膜操作、能量存储或屏蔽。传统的方法,如模塑和机械加工,往往难以制造复杂的多功能部件,如多孔支架、交叉电极和层状膜。相比之下,增材制造(AM)的进步已经改变了能源相关部件的生产,实现了更大的设计自由度、快速原型制作和定制、高性能部件的制造,同时减少了材料浪费。在不同类别的增材制造中,高性能聚合物(HPPs)由于其出色的热、机械和化学弹性而成为有希望的候选者。这些材料,包括聚酰胺(PA)、聚醚酰亚胺(PEI)、聚苯硫醚(PPS)、聚砜(PSU)、聚醚醚酮(PEEK)和聚酰亚胺(PI),特别适用于要求苛刻的能源应用中的增材制造。本文综述了近年来在电化学和热储能、制氢和储氢、油气系统和辐射屏蔽等方面的研究进展。它还研究了结构设计和复合材料增强如何提高性能,并概述了当前的挑战和未来的研究方向,以推进能源相关应用的增材制造技术。
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引用次数: 0
Graphene-functionalized biomaterials for bone and neural tissue engineering: bridging physicomechanical properties to multifunctionality bioapplications 骨和神经组织工程用石墨烯功能化生物材料:将物理力学性能与多功能生物应用相结合
Pub Date : 2025-12-05 DOI: 10.1016/j.smmf.2025.100092
Zi-Rui Luo , Tianyi Zeng , Chao-Chun Zhao , Kangling Xie , Ying Cai , Dengfeng Yin , Andrej Atrens , Ming-Chun Zhao
Recent advancements in graphene-functionalized (GNF) biomaterials have opened unprecedented avenues for bone and neural tissue regeneration. This review highlights the current advances in GNF biomaterials for bone and neural tissue regeneration in terms of their physicochemical and biological properties, and introduces the major categories of GNF biomaterials (ceramic/polymer/metal composites) and their physicochemical properties and applications in bone and neural tissue engineering. Also explored are the critical issues, challenges, and prospects in developing GNF biomaterials for bone and neural tissue engineering application. While existing reviews predominantly focus on graphene's general biomedical applications, this review uniquely addresses the dual-tissue regenerative potential of GNF biomaterials, emphasizing their synergistic physicomechanical properties and multifunctionality as well as translational challenges. First, we systematically analyze how GNF biomaterials overcome the distinct limitations of bone and neural repair: (i) For bone regeneration, GNF composites enhance mechanical strength, osteoconductivity, and antibacterial activity, while enabling photothermal tumor ablation in post-resection defects; (ii) For neural repair, GNF platforms promote electrical signal transduction, axonal guidance, and blood-brain barrier penetration, offering solutions for neurodegenerative diseases and traumatic injuries. Crucially, this review highlights three innovative dimensions: (1) Functional integration: GNF biomaterials uniquely combine antimicrobial properties, stem cell differentiation guidance, and drug delivery into a single platform, addressing infection risks, cellular microenvironment modulation, and targeted therapy simultaneously; (2) Emerging composites: Beyond conventional scaffolds, we explore cutting-edge applications such as flexible neural electrodes, degradable GNF-metal implants, and conductive hydrogels; (3) Clinical barriers: A critical discussion on long-term biocompatibility, industrial-scale synthesis, and toxicity mechanisms bridges the gap between laboratory innovation and clinical adoption. By synthesizing cross-disciplinary insights and proposing standardized evaluation frameworks, this review not only maps the current landscape but also charts a roadmap for developing clinically viable GNF-based therapies, which underscores the need for mechanistic studies on cellular interactions and large-scale safety assessments to accelerate the transition from experimental models to regenerative medicine breakthroughs.
石墨烯功能化(GNF)生物材料的最新进展为骨和神经组织再生开辟了前所未有的途径。本文综述了用于骨和神经组织再生的GNF生物材料的理化和生物学性能的研究进展,并介绍了GNF生物材料的主要类别(陶瓷/聚合物/金属复合材料)及其理化性能及其在骨和神经组织工程中的应用。本文还探讨了GNF生物材料在骨和神经组织工程应用中的关键问题、挑战和前景。虽然现有的综述主要集中在石墨烯的一般生物医学应用上,但这篇综述独特地讨论了GNF生物材料的双组织再生潜力,强调了它们的协同物理力学特性和多功能性以及转化挑战。首先,我们系统地分析了GNF生物材料如何克服骨和神经修复的明显局限性:(i)对于骨再生,GNF复合材料增强了机械强度、骨导电性和抗菌活性,同时在切除后的缺陷中实现了光热肿瘤消融;(ii)在神经修复方面,GNF平台促进电信号转导、轴突引导和血脑屏障穿透,为神经退行性疾病和创伤性损伤提供解决方案。重要的是,本综述强调了三个创新维度:(1)功能整合:GNF生物材料独特地将抗菌特性、干细胞分化指导和药物传递结合到一个单一平台中,同时解决感染风险、细胞微环境调节和靶向治疗;(2)新兴复合材料:除了传统的支架外,我们还探索了柔性神经电极、可降解gnf金属植入物和导电水凝胶等前沿应用;(3)临床障碍:对长期生物相容性、工业规模合成和毒性机制的关键讨论弥合了实验室创新与临床应用之间的差距。通过综合跨学科的见解和提出标准化的评估框架,这篇综述不仅描绘了当前的景观,而且为开发临床可行的基于gnf的疗法绘制了路线图,强调了细胞相互作用的机制研究和大规模安全性评估的必要性,以加速从实验模型到再生医学突破的过渡。
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引用次数: 0
Editorial: Insights into advances in additive manufacturing across materials systems 社论:洞察跨材料系统的增材制造进展
Pub Date : 2025-12-01 DOI: 10.1016/j.smmf.2025.100102
Pan Wang , Antonella Sola , Cuie Wen
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引用次数: 0
期刊
Smart Materials in Manufacturing
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