A compact modularized power-supply system for stable flow generation in microfluidic devices

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2023-10-19 DOI:10.1007/s10404-023-02693-w
Weihao Li, Wuyang Zhuge, Youwei Jiang, Kyle Jiang, Jun Ding, Xing Cheng
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Abstract

The miniaturization of microfluidic systems plays a pivotal role in achieving portability and compactness. However, conventional microfluidic systems heavily rely on external bulky facilities, such as syringe pumps and compressed air supplies, for continuous flow, which restricts their dissemination across various applications. To address this limitation, micropumps have emerged as a potential solution for portable power supply in microfluidic systems, with piezoelectric micropumps being widely adopted. Nonetheless, the inherent pulsatile mechanism of piezoelectric micropumps leads to unstable flow, necessitating appropriate mitigation for applications requiring flow stability. This research introduces an innovative hybrid pumping system that integrates a wirelessly controlled micropump with a 3D-printed modular microfluidic low-pass-filter. The primary objective of this system is to offer a portable and stable flow source for microfluidic applications. The system design and characterization are based on a three-element circuit model. Experimental results demonstrate a highly stabilized flow rate of 657 ± 7 µL/min. Furthermore, the versatility of the system is showcased by successfully forming droplets with a polydispersity ranging from 1.5% to 4%, comparable to that of bulky commercial pumping systems. This hybrid pumping system offers a promising solution for applications necessitating portable and stable flow sources, and its reconfigurability suggests potential integration into multifunctional microfluidic platforms.

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一种用于微流体装置中稳定流动产生的紧凑型模块化电源系统
微流体系统的小型化在实现便携性和紧凑性方面发挥着关键作用。然而,传统的微流体系统严重依赖外部庞大的设施,如注射泵和压缩空气供应,以实现连续流动,这限制了它们在各种应用中的传播。为了解决这一限制,微泵已成为微流体系统中便携式电源的潜在解决方案,压电微泵被广泛采用。尽管如此,压电微泵固有的脉动机制会导致流动不稳定,因此需要对需要流动稳定性的应用进行适当的缓解。本研究介绍了一种创新的混合泵送系统,该系统将无线控制的微型泵与3D打印的模块化微流体低通过滤器集成在一起。该系统的主要目标是为微流体应用提供便携式和稳定的流动源。系统的设计和表征是基于三元件电路模型。实验结果表明,657的流量高度稳定 ± 7µL/min。此外,该系统的多功能性通过成功形成多分散性在1.5%至4%范围内的液滴而得到展示,与大型商业泵送系统相当。这种混合泵送系统为需要便携式和稳定流源的应用提供了一种很有前途的解决方案,其可重新配置性表明有可能集成到多功能微流体平台中。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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