Flow rate variations in microfluidic circuits with free surfaces

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2023-10-19 DOI:10.1007/s10404-023-02691-y
Taha Messelmani, Isabela Zarpellon Nascimento, Eric Leclerc, Cécile Legallais, Adam Meziane, William César, Rachid Jellali, Anne Le Goff
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Abstract

We investigate analytically and experimentally the flow rate through a biochip in a circuit involving a peristaltic pump and reservoirs with liquid/air interfaces. Peristaltic pumps are a convenient way to achieve recirculation in microfluidic circuits. We consider different cases: reservoirs in contact with ambient air, tight reservoirs, and imperfect tightness leading to air or liquid leaks. We demonstrate that if changes in hydraulic resistance are slow enough, i.e., if cells do not proliferate too fast, the system may reach an equilibrium, with a difference in liquid height between inlet and outlet reservoir compensating the pressure drop in the biochip. We compute the flow rate through the biochip in the transient regime as well as the characteristic time. We also show that depending on the circuit dimensions, this equilibrium may never be reached. We provide guidelines to design tubings and reservoirs to avoid this situation and ensure a smooth recirculation at a desired flow rate, which is a necessary condition for dynamic cell culture.

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具有自由表面的微流体回路中的流速变化
我们通过分析和实验研究了在包括蠕动泵和具有液体/空气界面的储存器的电路中通过生物芯片的流速。蠕动泵是在微流体回路中实现再循环的一种方便方式。我们考虑不同的情况:储液器与环境空气接触,储液器密封,以及导致空气或液体泄漏的不完全密封。我们证明,如果水力阻力的变化足够慢,即如果细胞增殖不太快,系统可能会达到平衡,入口和出口储液器之间的液体高度差会补偿生物芯片中的压降。我们计算了在瞬态状态下通过生物芯片的流速以及特征时间。我们还表明,根据电路的尺寸,这种平衡可能永远不会达到。我们提供了设计管道和储液器的指南,以避免这种情况,并确保在所需流速下顺利再循环,这是动态细胞培养的必要条件。
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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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