STATs signaling pathways in dendritic cells: As potential therapeutic targets?

IF 4.3 4区医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2024-05-01 Epub Date: 2023-10-27 DOI:10.1080/08830185.2023.2274576

Sepideh Sohrabi, Javad Masoumi, Bahar Naseri, Farid Ghorbaninezhad, Shiva Alipour, Tohid Kazemi, Javad Ahmadian Heris, Leili Aghebati Maleki, Pedram Basirjafar, Raziyeh Zandvakili, Mohammad Amin Doustvandi, Behzad Baradaran

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Abstract

Dendritic cells (DCs) are professional antigen-presenting cells (APCs), including heterogenous populations with phenotypic and functional diversity that coordinate bridging innate and adaptive immunity. Signal transducer and activator of transcriptions (STAT) factors as key proteins in cytokine signaling were shown to play distinct roles in the maturation and antigen presentation of DCs and play a pivotal role in modulating immune responses mediated by DCs such as differentiation of T cells to T helper (Th) 1, Th2 or regulatory T (Treg) cells. This review sheds light on the importance of STAT transcription factors' signaling pathways in different subtypes of DCs and highlights their targeting potential usages for improving DC-based immunotherapies for patients who suffer from cancer or diverse autoimmune conditions according to the type of the STAT transcription factor and its specific activating or inhibitory agent.

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树突状细胞中的STATs信号通路：作为潜在的治疗靶点？

树突状细胞（DC）是专业的抗原呈递细胞（APC），包括具有表型和功能多样性的异质群体，协调先天免疫和适应性免疫。信号转导子和转录激活子（STAT）因子作为细胞因子信号传导中的关键蛋白，在DC的成熟和抗原呈递中发挥着不同的作用，并在调节DC介导的免疫反应中发挥着关键作用，如T细胞分化为T辅助细胞（Th）1、Th2或调节性T细胞（Treg）。这篇综述阐明了STAT转录因子信号通路在不同亚型DC中的重要性，并强调了其靶向潜在用途，根据STAT转录因素的类型及其特异性激活或抑制剂，改善癌症或多种自身免疫疾病患者的DC基免疫疗法。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).

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