A Review on Novel Applications of Nanotechnology in the Management of Prostate Cancer.

Arshi Khanam, Gurvirender Singh, Smita Narwal, Bhawna Chopra, Ashwani K Dhingra
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Abstract

Background: Prostate cancer continues to be a serious danger to men's health, despite advances in the field of cancer nanotechnology. Although different types of cancer have been studied using nanomaterials and theranostic systems derived from nanomaterials, they have not yet reached their full potential for prostate cancer due to issues with in vivo biologic compatibility, immune reaction responses, accurate targetability, as well as a therapeutic outcome related to the nano-structured mechanism.

Method: The ultimate motive of this article is to understand the theranostic nanotechnology-based scheme for treating prostate cancer. The categorization of diverse nanomaterials in accordance with biofunctionalization tactics and biomolecule sources has been emphasized in this review so that they might potentially be used in clinical contexts and future advances. These opportunities can enhance the direct visualization of prostate tumors, early identification of prostate cancer-associated biomarkers at extremely low detection limits, and finally, the therapy for prostate cancer.

Result: In December 2022, a thorough examination of the scientific literature was carried out utilizing the Web of Science, PubMed, and Medline databases. The goal was to analyze novel applications of nanotechnology in the treatment of prostate cancer, together with their structural layouts and functionalities.

Conclusion: The various treatments and the reported revolutionary nanotechnology-based systems appear to be precise, safe, and generally successful; as a result, this might open up a new avenue for the detection and eradication of prostate cancer.

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纳米技术在癌症治疗中的新应用综述。
背景:尽管癌症纳米技术领域取得了进展,但前列腺癌症仍然是男性健康的严重威胁。尽管已经使用纳米材料和衍生自纳米材料的治疗系统研究了不同类型的癌症,但由于体内生物相容性、免疫反应反应反应、精确靶向性以及与纳米结构机制相关的治疗结果等问题,它们尚未充分发挥其治疗癌症的潜力。方法:本文的最终目的是了解基于纳米技术的前列腺癌症治疗方案。本综述强调了根据生物功能化策略和生物分子来源对各种纳米材料进行分类,以便它们有可能用于临床和未来的进展。这些机会可以增强前列腺肿瘤的直接可视化,以极低的检测极限早期识别前列腺癌相关生物标志物,并最终促进癌症的治疗。结果:2022年12月,利用Web of Science、PubMed和Medline数据库对科学文献进行了彻底检查。目的是分析纳米技术在治疗癌症方面的新应用,以及它们的结构布局和功能。结论:各种治疗方法和报道的革命性的基于纳米技术的系统似乎是精确、安全和普遍成功的;因此,这可能为检测和根除癌症开辟一条新的途径。
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