{"title":"Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals","authors":"Hou-Ling Wang , Hongwei Guo , Zhonghai Li","doi":"10.1016/j.tma.2018.12.003","DOIUrl":null,"url":null,"abstract":"<div><p>Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention has been proved to be as feasible approaches. NAD<sup>+</sup>, spermidine, and rapamycin, as well as genetic editing, bring to light at the tunnel end for the longevity in animals. In plants, the existing evidence suggests that they may share common aging signaling pathway with animals. However, as sessile organisms, plants got to cope with complex environmental changes and evolved specific signaling pathways. Here, we reviewed the latest research advances in plant aging to make a gene network analysis of senescence-associated genes in annual plant and perform a comparative assessment of aging in perennials as well as animals.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 6-13"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2018.12.003","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Medicine of Aging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468501118300087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 4
Abstract
Aging, resulting from degenerative changes in cell metabolism, affects fecundity and longevity. To increase lifespan in animals or plants, manipulation in gene modification or pharmacology intervention has been proved to be as feasible approaches. NAD+, spermidine, and rapamycin, as well as genetic editing, bring to light at the tunnel end for the longevity in animals. In plants, the existing evidence suggests that they may share common aging signaling pathway with animals. However, as sessile organisms, plants got to cope with complex environmental changes and evolved specific signaling pathways. Here, we reviewed the latest research advances in plant aging to make a gene network analysis of senescence-associated genes in annual plant and perform a comparative assessment of aging in perennials as well as animals.
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