Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2022-12-01 DOI:10.1016/j.phanu.2022.100316

Carla Dayana Durães Abreu , Bruna Viana Caldas , Guilherme Henrique Mendes Ribeiro , Charles Martins Aguilar , Lucyana Conceição Farias , André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Maria Beatriz Abreu Glória , Sérgio Henrique Sousa Santos

{"title":"Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissue","authors":"Carla Dayana Durães Abreu , Bruna Viana Caldas , Guilherme Henrique Mendes Ribeiro , Charles Martins Aguilar , Lucyana Conceição Farias , André Luiz Sena Guimarães , Alfredo Maurício Batista de Paula , Maria Beatriz Abreu Glória , Sérgio Henrique Sousa Santos","doi":"10.1016/j.phanu.2022.100316","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span><span>Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. </span>Probiotic </span>dietary supplementation is a viable health option.</p></div><div><h3>Methods</h3><p><span>Male Swiss mice<span> were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in </span></span>adipose tissue were analyzed.</p></div><div><h3>Results</h3><p><span>The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein<span> gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving </span></span>insulin sensitivity.</p></div><div><h3>Conclusion</h3><p>The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.</p></div><div><h3>Data Availability Statement</h3><p>The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.</p></div>","PeriodicalId":20049,"journal":{"name":"PharmaNutrition","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PharmaNutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213434422000299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 2

Abstract

Background

Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. Probiotic dietary supplementation is a viable health option.

Methods

Male Swiss mice were fed with two diets for four weeks: standard and standard + Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in adipose tissue were analyzed.

Results

The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving insulin sensitivity.

Conclusion

The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative.

Data Availability Statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

饲粮中添加菊粉可通过降低脂肪组织中toll样受体4跨膜蛋白基因和白细胞介素6的表达来改善代谢参数

生活方式的改变增加了世界范围内超加工食品、脂肪、糖和盐的消费量，同时由于豆类、谷物和蔬菜摄入量的减少，膳食纤维也减少了。最终，当代食物摄入状况增加了肥胖和慢性炎症疾病的发病率。益生菌膳食补充剂是一种可行的健康选择。方法采用标准饲粮和标准饲粮+菊粉两种饲粮喂养4周。分析血清生化、组织学及脂肪组织炎症相关基因mRNA表达情况。结果饲粮中添加菊粉可降低附睾脂肪组织中toll样受体4跨膜蛋白基因(TLR4)和白细胞介素6 (IL6)的表达，导致脂肪细胞肥厚减少。高密度脂蛋白(HDL)升高，TGP酶(与肝损伤风险相关)降低，并改善胰岛素敏感性。结论补充菊粉可以改善脂肪组织中慢性炎症相关标志物的发生，提示菊粉是一种天然的抗炎替代品。数据可用性声明当前研究期间生成和/或分析的数据集可根据通讯作者的合理要求提供。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊