Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges

Abstract

In this paper we employ an improved thalamo-cortical model to uncover the potential generation mechanisms of pS-WD patterns by means of bursting oscillation's analysis approaches in the process of seizures generation at both fast and slow timescales. Interestingly, it is found that the onset of epileptic discharges can be delayed as an increase of excitatory regulating function of the thalamic relay neuronal population on cortical PY. The obtained numerical results show that the initiation of absence seizures arises from the thalamus and the termination of them in the cortex.