Taurine improves lipid profile in rats fed a high fructose-diet

IF 3.1 3区医学 Q2 NUTRITION & DIETETICS Nutrition Research Pub Date : 2002-03-01 DOI:10.1016/S0271-5317(01)00391-8

A.T. Anitha Nandhini , S.D. Balakrishnan , C.V. Anuradha

{"title":"Taurine improves lipid profile in rats fed a high fructose-diet","authors":"A.T. Anitha Nandhini , S.D. Balakrishnan , C.V. Anuradha","doi":"10.1016/S0271-5317(01)00391-8","DOIUrl":null,"url":null,"abstract":"<div><div><span><span><span><span>The effect of taurine on lipid metabolism in male Wistar rats fed a fructose-rich diet (60%w/w) was investigated. Fructose feeding caused significant elevations in the concentrations of </span>plasma triglycerides and </span>free fatty acids. High-density lipoprotein cholesterol (HDL-C) was significantly reduced and very low-density lipoprotein cholesterol (VLDL-C) was significantly elevated. Activities of </span>lipoprotein lipase (LPL) and </span>lecithin cholesterol acyl transferase<span><span><span> (LCAT) in plasma were reduced significantly (p<0.001) as compared to animals fed starch diet. Alterations in the activities of plasma cholesterol<span> ester hydrolase (CEH) and </span></span>cholesterol ester synthetase<span> (CES) were observed in fructose-fed rats. Fructose feeding also induced alterations in fatty acid composition of </span></span>liver lipids. Simultaneous administration of taurine in drinking water along with fructose diet mitigated the effects of fructose. These rats showed near-normal levels of the parameters studied. We conclude that taurine normalizes the plasma and liver lipid alterations in this nutritional experimental model.</span></div></div>","PeriodicalId":19245,"journal":{"name":"Nutrition Research","volume":"22 3","pages":"Pages 343-354"},"PeriodicalIF":3.1000,"publicationDate":"2002-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0271531701003918","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

The effect of taurine on lipid metabolism in male Wistar rats fed a fructose-rich diet (60%w/w) was investigated. Fructose feeding caused significant elevations in the concentrations of plasma triglycerides and free fatty acids. High-density lipoprotein cholesterol (HDL-C) was significantly reduced and very low-density lipoprotein cholesterol (VLDL-C) was significantly elevated. Activities of lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) in plasma were reduced significantly (p<0.001) as compared to animals fed starch diet. Alterations in the activities of plasma cholesterol ester hydrolase (CEH) and cholesterol ester synthetase (CES) were observed in fructose-fed rats. Fructose feeding also induced alterations in fatty acid composition of liver lipids. Simultaneous administration of taurine in drinking water along with fructose diet mitigated the effects of fructose. These rats showed near-normal levels of the parameters studied. We conclude that taurine normalizes the plasma and liver lipid alterations in this nutritional experimental model.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

牛磺酸可以改善高果糖饮食的老鼠的脂质状况

研究了牛磺酸对Wistar雄性大鼠富果糖饮食（60%w/w）脂肪代谢的影响。果糖喂养导致血浆甘油三酯和游离脂肪酸浓度显著升高。高密度脂蛋白胆固醇（HDL-C）显著降低，极低密度脂蛋白胆固醇（VLDL-C）显著升高。血浆脂蛋白脂肪酶（LPL）和卵磷脂胆固醇酰基转移酶（LCAT）活性显著降低（p < 0.001）。观察了果糖饲喂大鼠血浆胆固醇酯水解酶（CEH）和胆固醇酯合成酶（CES）活性的变化。果糖喂养也会引起肝脏脂质脂肪酸组成的改变。同时在饮用水中加入牛磺酸和果糖饮食可以减轻果糖的影响。这些大鼠显示出接近正常水平的参数。我们得出结论，牛磺酸使这个营养实验模型中的血浆和肝脏脂质改变正常化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.