The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in Arabidopsis

IF 9.3 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Integrative Plant Biology Pub Date : 2022-08-16 DOI:10.1111/jipb.13345
Tao Li, Ruyue Zhang, Viswanathan Satheesh, Peng Wang, Guojie Ma, Jianfei Guo, Guo-Yong An, Mingguang Lei
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引用次数: 4

Abstract

Plasticity in root system architecture (RSA) allows plants to adapt to changing nutritional status in the soil. Phosphorus availability is a major determinant of crop yield, and RSA remodeling is critical to increasing the efficiency of phosphorus acquisition. Although substantial progress has been made in understanding the signaling mechanism driving phosphate starvation responses in plants, whether and how epigenetic regulatory mechanisms contribute is poorly understood. Here, we report that the Switch defective/sucrose non-fermentable (SWI/SNF) ATPase BRAHMA (BRM) is involved in the local response to phosphate (Pi) starvation. The loss of BRM function induces iron (Fe) accumulation through increased LOW PHOSPHATE ROOT1 (LPR1) and LPR2 expression, reducing primary root length under Pi deficiency. We also demonstrate that BRM recruits the histone deacetylase (HDA) complex HDA6-HDC1 to facilitate histone H3 deacetylation at LPR loci, thereby negatively regulating local Pi deficiency responses. BRM is degraded under Pi deficiency conditions through the 26 S proteasome pathway, leading to increased histone H3 acetylation at the LPR loci. Collectively, our data suggest that the chromatin remodeler BRM, in concert with HDA6, negatively regulates Fe-dependent local Pi starvation responses by transcriptionally repressing the RSA-related genes LPR1 and LPR2 in Arabidopsis thaliana.

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染色质重塑者BRAHMA招募组蛋白去乙酰化lase6来调节拟南芥对磷酸盐饥饿的根生长抑制
根系结构的可塑性使植物能够适应土壤中不断变化的营养状况。磷的有效性是作物产量的主要决定因素,而RSA重塑是提高磷吸收效率的关键。尽管在了解驱动植物磷酸盐饥饿反应的信号机制方面取得了实质性进展,但表观遗传调控机制是否以及如何起作用尚不清楚。在这里,我们报道了开关缺陷/蔗糖不可发酵(SWI/SNF) atp酶BRAHMA (BRM)参与了对磷酸盐(Pi)饥饿的局部响应。缺磷条件下,BRM功能的丧失通过增加低磷酸根1 (LOW PHOSPHATE ROOT1, LPR1)和LPR2表达诱导铁(Fe)积累,减少主根长度。我们还证明BRM招募组蛋白去乙酰化酶(HDA)复合物HDA6-HDC1促进LPR位点的组蛋白H3去乙酰化,从而负性调节局部Pi缺乏症反应。在Pi缺乏条件下,BRM通过26 S蛋白酶体途径降解,导致LPR位点组蛋白H3乙酰化增加。总的来说,我们的数据表明,染色质重塑器BRM与HDA6一起,通过转录抑制rsa相关基因LPR1和LPR2,负向调节拟南芥中fe依赖的局部Pi饥饿反应。
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来源期刊
Journal of Integrative Plant Biology
Journal of Integrative Plant Biology 生物-生化与分子生物学
CiteScore
18.00
自引率
5.30%
发文量
220
审稿时长
3 months
期刊介绍: Journal of Integrative Plant Biology is a leading academic journal reporting on the latest discoveries in plant biology.Enjoy the latest news and developments in the field, understand new and improved methods and research tools, and explore basic biological questions through reproducible experimental design, using genetic, biochemical, cell and molecular biological methods, and statistical analyses.
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