A. Hunt, U. Haberkorn, J. Schröder, P. Schönknecht
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引用次数: 5
Abstract
Executive function is frequently impaired in patients with Alzheimer’s disease (AD) and its prodromal stage, and can be assessed using the Trail-Making Test (TMT). We aimed to elicit the neural and cognitive correlates of TMT subtests using positron emission tomography with 18-fluoro-D-deoxy-glucose, and neuropsychological testing in 20 patients with prodromal or manifest AD as well as 14 controls. TMT-A correlated with glucose metabolism in the left middle frontal cortex, TMT-B performance correlated with the metabolism in the right middle frontal cortex and the right precentral gyrus, and TMT-Q performance correlated with metabolism in the right middle frontal cortex. The present findings reveal functional imaging evidence that executive dysfunction in AD as measured by TMT is frontal lobe mediated.
阿尔茨海默病(AD)及其前驱期患者的执行功能经常受损，可以使用Trail-Making Test (TMT)进行评估。我们的目的是利用正电子发射断层扫描和18-氟-d -脱氧葡萄糖，在20名前驱或明显AD患者以及14名对照患者中进行神经和认知测试。TMT-A与左侧额叶中皮质的葡萄糖代谢相关，TMT-B与右侧额叶中皮质和右侧中央前回的代谢相关，TMT-Q与右侧额叶中皮质的代谢相关。本研究结果揭示了功能成像证据，表明TMT测量的AD执行功能障碍是额叶介导的。
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