{"title":"Web alert: Metagenomic mining for biotechnology","authors":"Lawrence P. Wackett","doi":"10.1111/1751-7915.14334","DOIUrl":null,"url":null,"abstract":"<p>Mining terpene synthases</p><p>\n https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-022-02189-9\n </p><p>Terpenes are an industrially important and highly abundant class of natural products. This review discussed mining of soil microbial genomes for genes encoding known and novel terpenoid compounds.</p><p>Metagenomic analysis for new pectinases</p><p>\n https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-017-0885-y\n </p><p>This study looked a specific microbiome connected to apple compost to find new pectinolytic enzymes.</p><p>Repurposing CRISPRi for metagenomic mining</p><p>\n https://www.nature.com/articles/s41587-022-01563-0\n </p><p>This study in <i>Nature Biotechnology</i> describes a new CRISPR-interference method to rapidly mine metagenomic and genomic sequences. This journal is not available without subscription, but is available through many institutional libraries.</p><p>Metagenomic mining for natural products</p><p>\n https://www.biorxiv.org/content/10.1101/2021.01.20.427441v1.full\n </p><p>This article on a preprint server for biological studies describes a tool for rapid mining of microbial biosynthetic gene clusters.</p><p>Mining enzyme diversity</p><p>\n https://link.springer.com/referenceworkentry/10.1007/978-3-319-31421-1_216-1\n </p><p>This review book chapter focuses on metagenomic mining for new enzyme diversity.</p><p>Microfluidics and metagenome mining</p><p>\n https://www.liebertpub.com/doi/10.1089/crispr.2022.0054\n </p><p>This paper describes a high-throughput, microfluidic method to enrich rare sequences in a metagenomic mixture.</p><p>Mining hidden biosynthetic potential</p><p>\n https://www.nature.com/articles/s41467-021-24133-5\n </p><p>This is a review article in an open-source journal, <i>Nature Communications,</i> focused on mining for secondary metabolites.</p><p>Long-read metagenomics of marine microbes</p><p>\n https://journals.asm.org/doi/10.1128/spectrum.01501-23\n </p><p>Long-read sequencing is important for discovering biosynthetic gene clusters, which are often comprised of dozens of contiguous genes.</p><p>Hunting down enzymes</p><p>\n https://elifesciences.org/digests/70021/hunting-down-enzymes\n </p><p>This magazine style article describes tools for analysing genomes to find new enzymes that modify DNA.</p><p>MGnify database</p><p>\n https://www.ebi.ac.uk/metagenomics\n </p><p>MGnify is a database and platform that can be used to assemble, analyse and archive microbiome-derived nucleic acid sequences.</p><p>MGnify genomes</p><p>\n https://www.sciencedirect.com/science/article/pii/S0022283623000724\n </p><p>This recent paper describes MGnify Genomes, an extension of the MGnify database. This resource includes the increasing availability of biome-specific metagenome-assembled genomes (MAGs).</p><p>Metagenome submission guide</p><p>\n https://www.ncbi.nlm.nih.gov/genbank/metagenome/\n </p><p>This page offers information for submitting metagenome project sequences to the National Center for Biotechnology Information (NCBI).</p>","PeriodicalId":49145,"journal":{"name":"Microbial Biotechnology","volume":"16 9","pages":"1872-1873"},"PeriodicalIF":4.8000,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.14334","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1751-7915.14334","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Terpenes are an industrially important and highly abundant class of natural products. This review discussed mining of soil microbial genomes for genes encoding known and novel terpenoid compounds.
This study in Nature Biotechnology describes a new CRISPR-interference method to rapidly mine metagenomic and genomic sequences. This journal is not available without subscription, but is available through many institutional libraries.
This recent paper describes MGnify Genomes, an extension of the MGnify database. This resource includes the increasing availability of biome-specific metagenome-assembled genomes (MAGs).
Metagenome submission guide
https://www.ncbi.nlm.nih.gov/genbank/metagenome/
This page offers information for submitting metagenome project sequences to the National Center for Biotechnology Information (NCBI).
期刊介绍：
Microbial Biotechnology publishes papers of original research reporting significant advances in any aspect of microbial applications, including, but not limited to biotechnologies related to: Green chemistry; Primary metabolites; Food, beverages and supplements; Secondary metabolites and natural products; Pharmaceuticals; Diagnostics; Agriculture; Bioenergy; Biomining, including oil recovery and processing; Bioremediation; Biopolymers, biomaterials; Bionanotechnology; Biosurfactants and bioemulsifiers; Compatible solutes and bioprotectants; Biosensors, monitoring systems, quantitative microbial risk assessment; Technology development; Protein engineering; Functional genomics; Metabolic engineering; Metabolic design; Systems analysis, modelling; Process engineering; Biologically-based analytical methods; Microbially-based strategies in public health; Microbially-based strategies to influence global processes
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