Stereoselective Construction of (E,Z)‐1,3‐Dienes and Its Application in Natural Product Synthesis

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2020-12-01 DOI:10.1002/adsc.202000730
Pierre Hubert , Elena Seibel , Christine Beemelmanns , Jean‐Marc Campagne , Renata Marcia de Figueiredo
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引用次数: 21

Abstract

The E,Z‐configured 1,3‐diene unit is a common motif in numerous bioactive natural products. Although several powerful methods are available to produce these motifs with high levels of selectivity, their construction within a complex, polyfunctionalised structure, such as a natural product, requires well‐defined strategies to avoid undesirable reactions and low‐to‐moderate selectivities. The aim of this review is to provide a full account of the stereoselective strategies for building E,Z‐configured 1,3‐dienes, as well as to highlight selected total syntheses that employ them.

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(E,Z)‐1,3‐二烯的立体选择性结构及其在天然产物合成中的应用
E,Z -构型1,3 -二烯单元是许多生物活性天然产物中的常见基序。虽然有几种有效的方法可以产生具有高选择性的这些基序,但它们在复杂的多功能化结构(如天然产物)中的构建需要明确的策略来避免不良反应和中低选择性。本综述的目的是全面介绍构建E,Z构型1,3二烯的立体选择策略,并重点介绍采用这些策略的全合成方法。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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