Peroxisome Proliferator Activated Receptor σ (pPARσ) Agonists and Their Role on Epilepsy-Induced Seizures: An Experimental Evaluative Study

Abstract

To evaluate the anticonvulsant activity of propranolol in Wistar albino rats by maximal electroshock (MES)-induced seizure model. study CPCSEA Healthy, adult Wistar albino rats of either sex 180 and 250 g were used for the study. The animals were procured from the central animal house and were acclimatized in the experimental laboratory for 7 days. The study consisted of three groups with six animals in each group. Group I: control (equivalent volume of normal saline, i.p.); group II: diphenylhydantoin (25 mg/kg BW, i.p.); group III: propranolol (i.p.). Anticonvulsant activity in Wistar albino rats was assessed by MES model. The data were expressed as median ± SE. Statistical significance among study groups was carried using Graph Pad Instat Software, by ANOVA test followed by Bonferroni’s post hoc test. Results: In group II (standard) all animals were pro-tected by absence of THLE when compared with group I (control). Group II also exhibited significant decline in scores when compared with control group. Administration of propranolol in groups III also showed significant percent decline in THLE as well as scores when compared with group I. Percent decline in THLE and scores in group III were comparable to the group II. Conclusion: anticonvulsant activity in MES in rats. and test independent variables— tests associates and complex factors impact of on adherence to antiepileptic drugs in in the Methods: The setting of the study was provided by community care trial of home-based care delivered by primary health care workers versus routine clinic-based care. We studied the association between monthly pill counts and self-reported adherence questionnaire score with age, gen-der, religion, ethnic origin, education, occupation, monthly family income, and socioeconomic class. In addition, we cre-ated a dummy variable, which represented baseline scores for each subject. Results: There was considerable inter individual varia-tions on pill count and SRMS score. Overall, lag SRMS, religion, ethnic origin, and monthly family income determined adherence status. A steady increase in the proportion of people with appropriate pill count was observed in the home-based care group but not in the clinic-based care group. Conclusion: adherence varies consider-ably between individuals and is influenced by individual behavior. However, repeated adherence reinforcement by primary health care workers may lead to improvement in adherence.