{"title":"Colic Motor Complex of the Cecum and Proximal Loop of the Ascending Colon Observed in an Experimental Cow with Large Intestinal Obstruction*","authors":"A. Steiner, A. J. Roussel, W. C. Ellis","doi":"10.1111/j.1439-0442.1994.tb00065.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Myoelectric activity of the cecum and proximal loop of the ascending colon (PLAC) and the effect of xylazine on motility of this intestinal segment in an experimental cow with large intestinal obstruction are described and compared with the normal motility pattern. During obstruction, three major observations were made in the prestenotic area, (i) Mean spike duration, overall duration of spiking activity (expressed as percentage of total recording time), number of spikes propagated from the cecum towards the obstruction site, and velocity of propagated spikes were substantially increased, (ii) The spike frequency was in the physiologic range, (iii) A single injection of xylazine, administered intravenously at a dose of 0.05 mg/kg markedly reduced the mean spike duration, the overall spiking activity, and the number of propagated spike sequences, and abolished signs of abdominal discomfort. Our data indicate that obstruction of the bovine colon causes a similar pattern of prestenotic hypermotility (colic motor complex) as described for the small intestine of the horse. Xylazine may be a suitable drug to disrupt prestenotic hypermotility and alleviate abdominal discomfort during proximal colonic obstruction in cattle.</p>\n </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"41 1-10","pages":"53-61"},"PeriodicalIF":3.5000,"publicationDate":"1994-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1439-0442.1994.tb00065.x","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transboundary and Emerging Diseases","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0442.1994.tb00065.x","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 14
Abstract
Myoelectric activity of the cecum and proximal loop of the ascending colon (PLAC) and the effect of xylazine on motility of this intestinal segment in an experimental cow with large intestinal obstruction are described and compared with the normal motility pattern. During obstruction, three major observations were made in the prestenotic area, (i) Mean spike duration, overall duration of spiking activity (expressed as percentage of total recording time), number of spikes propagated from the cecum towards the obstruction site, and velocity of propagated spikes were substantially increased, (ii) The spike frequency was in the physiologic range, (iii) A single injection of xylazine, administered intravenously at a dose of 0.05 mg/kg markedly reduced the mean spike duration, the overall spiking activity, and the number of propagated spike sequences, and abolished signs of abdominal discomfort. Our data indicate that obstruction of the bovine colon causes a similar pattern of prestenotic hypermotility (colic motor complex) as described for the small intestine of the horse. Xylazine may be a suitable drug to disrupt prestenotic hypermotility and alleviate abdominal discomfort during proximal colonic obstruction in cattle.
期刊介绍：
Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions):
Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread.
Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope.
Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies.
Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies).
Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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