{"title":"Clinical Connections","authors":"","doi":"10.1002/art.42207","DOIUrl":null,"url":null,"abstract":"cleavage of gasdermin superfamily proteins, leading to the formation of membrane pores. The formation of pores and the increased permeability of cell membranes promote the release of cellular contents that trigger and sustain inflammation. Ebata et al found that inhibiting noncanonical pyroptosis in chondrocytes suppressed the production of catabolic factors in vitro and cartilage degeneration in vivo. These data demonstrate that pyroptosis signaling represents an attractive target for preventing car tilage degeneration and the progression of OA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"75 8","pages":""},"PeriodicalIF":11.4000,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42207","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arthritis & Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/art.42207","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
cleavage of gasdermin superfamily proteins, leading to the formation of membrane pores. The formation of pores and the increased permeability of cell membranes promote the release of cellular contents that trigger and sustain inflammation. Ebata et al found that inhibiting noncanonical pyroptosis in chondrocytes suppressed the production of catabolic factors in vitro and cartilage degeneration in vivo. These data demonstrate that pyroptosis signaling represents an attractive target for preventing car tilage degeneration and the progression of OA.
期刊介绍：
Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.
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