{"title":"Beyond Joint Pain – Expanding Insights on the Impact of Nonarticular Pain in Early Rheumatoid Arthritis","authors":"Yumei Zhong, Rui Lai, Xinmin Deng","doi":"10.1002/art.43160","DOIUrl":"https://doi.org/10.1002/art.43160","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"101 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qianlin Weng, Ting Jiang, Tuo Yang, Yuqing Zhang, Weiya Zhang, Michael Doherty, Jie Wei, Yilun Wang, Guanghua Lei, Chao Zeng
Intramuscular fat infiltration (IMFI) in the thigh is linked to metabolic inflammation and muscle dysfunction, which could contribute to osteoarthritis development. However, no longitudinal studies have examined the associations between thigh IMFI and incident knee and hip osteoarthritis.
{"title":"Association of thigh intramuscular fat infiltration with incident knee and hip osteoarthritis: a longitudinal cohort study","authors":"Qianlin Weng, Ting Jiang, Tuo Yang, Yuqing Zhang, Weiya Zhang, Michael Doherty, Jie Wei, Yilun Wang, Guanghua Lei, Chao Zeng","doi":"10.1002/art.43159","DOIUrl":"https://doi.org/10.1002/art.43159","url":null,"abstract":"Intramuscular fat infiltration (IMFI) in the thigh is linked to metabolic inflammation and muscle dysfunction, which could contribute to osteoarthritis development. However, no longitudinal studies have examined the associations between thigh IMFI and incident knee and hip osteoarthritis.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"61 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles L Bennett, Jason B Gibbons, Chadi Nabhan, Kenneth R Carson, June M McKoy, Kevin B Knopf, Gerald Anderson
Click on the article title to read more.
{"title":"Notes from the field: The Inflation Reduction Act and Enbrel","authors":"Charles L Bennett, Jason B Gibbons, Chadi Nabhan, Kenneth R Carson, June M McKoy, Kevin B Knopf, Gerald Anderson","doi":"10.1002/art.43153","DOIUrl":"https://doi.org/10.1002/art.43153","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson
Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.
{"title":"Sex Differences in B Cells from the Joints of Children with Oligoarticular Juvenile Idiopathic Arthritis","authors":"Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson","doi":"10.1002/art.43157","DOIUrl":"https://doi.org/10.1002/art.43157","url":null,"abstract":"Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar
To assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.
{"title":"Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study","authors":"Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar","doi":"10.1002/art.43155","DOIUrl":"https://doi.org/10.1002/art.43155","url":null,"abstract":"To assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam
This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).
{"title":"Effects of secukinumab on enthesiophyte and erosion progression in psoriatic arthritis –a one-year double-blind, randomized, placebo-controlled trial utilizing high-resolution peripheral quantitative computed tomography","authors":"Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam","doi":"10.1002/art.43154","DOIUrl":"https://doi.org/10.1002/art.43154","url":null,"abstract":"This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David S Pisetsky, Jennifer L Rogers, Amanda M Eudy, Katherine T Martucci, Ru-Rong Ji, Peter E Lipsky
{"title":"Nociplasticity: A Proposed Concept to Understand the Symptomatology of Systemic Lupus Erythematosus.","authors":"David S Pisetsky, Jennifer L Rogers, Amanda M Eudy, Katherine T Martucci, Ru-Rong Ji, Peter E Lipsky","doi":"10.1002/art.43152","DOIUrl":"https://doi.org/10.1002/art.43152","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thuong Trinh-Minh, Cuong Tran-Manh, Andrea-Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H W Distler
Objectives: Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case-specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options. Here, we evaluated the therapeutic effects of the highly selective 5-hydroxytryptamine 2B receptor (5-HT2BR) inhibitor AM1476.
Methods: The antifibrotic effects of AM1476 were evaluated in the mouse models of bleomycin-induced pulmonary fibrosis, in tight-skin-1 (Tsk-1) mice and in mice with sclerodermatous chronic graft-versus-host disease (cGvHD). For further validation, the antifibrotic effects of AM1476 were analyzed in precision cut skin (PCS) slices from SSc patients.
Results: AM1476 demonstrated high selectivity for 5-HT2BR over more than 200 other receptors including other 5-HT receptors in vitro. AM1476 reduced accumulation of hydroxyproline and fibrotic tissue remodeling of skin and/or lung in all three mouse models at well tolerated doses with a comparable efficacy to that of Nintedanib. In PCS of SSc skin, treatment with AM1476 reduced the expression of SSc-specific signature genes. AM1476 demonstrated more pronounced regulation of terms related to fibroblast activation and fibrotic remodeling than mycophenolate mofetil (MMF).
Conclusions: We describe AM1476 as a highly selective inhibitor of 5-HT2BR. Treatment with AM1476 ameliorated fibrosis in three mouse models of SSc and normalized the expression of fibrosis-related genes directly in SSc skin. As AM1476 also demonstrated good tolerability in a phase I trial, further clinical trials with AM1476 are currently in the planning stage.
{"title":"Specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT<sub>2B</sub>R) demonstrates antifibrotic effects in murine models and ex vivo models of scleroderma skin.","authors":"Thuong Trinh-Minh, Cuong Tran-Manh, Andrea-Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H W Distler","doi":"10.1002/art.43151","DOIUrl":"https://doi.org/10.1002/art.43151","url":null,"abstract":"<p><strong>Objectives: </strong>Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case-specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options. Here, we evaluated the therapeutic effects of the highly selective 5-hydroxytryptamine 2B receptor (5-HT<sub>2B</sub>R) inhibitor AM1476.</p><p><strong>Methods: </strong>The antifibrotic effects of AM1476 were evaluated in the mouse models of bleomycin-induced pulmonary fibrosis, in tight-skin-1 (Tsk-1) mice and in mice with sclerodermatous chronic graft-versus-host disease (cGvHD). For further validation, the antifibrotic effects of AM1476 were analyzed in precision cut skin (PCS) slices from SSc patients.</p><p><strong>Results: </strong>AM1476 demonstrated high selectivity for 5-HT<sub>2B</sub>R over more than 200 other receptors including other 5-HT receptors in vitro. AM1476 reduced accumulation of hydroxyproline and fibrotic tissue remodeling of skin and/or lung in all three mouse models at well tolerated doses with a comparable efficacy to that of Nintedanib. In PCS of SSc skin, treatment with AM1476 reduced the expression of SSc-specific signature genes. AM1476 demonstrated more pronounced regulation of terms related to fibroblast activation and fibrotic remodeling than mycophenolate mofetil (MMF).</p><p><strong>Conclusions: </strong>We describe AM1476 as a highly selective inhibitor of 5-HT<sub>2B</sub>R. Treatment with AM1476 ameliorated fibrosis in three mouse models of SSc and normalized the expression of fibrosis-related genes directly in SSc skin. As AM1476 also demonstrated good tolerability in a phase I trial, further clinical trials with AM1476 are currently in the planning stage.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anu Sreekanth, Justin George, Sakir Ahmed, Pankti Mehta, Sanjo Saijan, Aparna R Menon, Bhowmik Meghnathi, Padmanabha Shenoy D
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{"title":"Minimal Tofacitinib dose for Maintenance in Axial Spondyloarthritis: Real world data from a Resource-limited setting","authors":"Anu Sreekanth, Justin George, Sakir Ahmed, Pankti Mehta, Sanjo Saijan, Aparna R Menon, Bhowmik Meghnathi, Padmanabha Shenoy D","doi":"10.1002/art.43147","DOIUrl":"https://doi.org/10.1002/art.43147","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"5 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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