Association of Genetic Markers with Mental Retardation

T.L. Pathi, M. Ramesh, S. Krishnasubha, V. Kalpana, G. Sudhakar
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Abstract

Abstract Five red cell genetic markers namely, acid phosphatase locus 1 (ACP1), esterase D (ESD), glyoxalase locus 1 (GLO1), superoxide dismutase (SOD) and haemoglobin (HB) and five plasma proteins namely haptoglobin (HP), ceruloplasmin (CP), group specific component (GC), transferrin (TF) and albumin (ALB) were studied in mentally retarded individuals from Visakhapatnam area of north coastal Andhra Pradesh, South India. The results were compared with the data obtained from controls. Out of studied ten genetic markers, two namely ACP1 and HP showed significant differences between patients and controls. The risk estimates were also showing a significant association.
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遗传标记与智力迟钝的关系
摘要研究了印度南部安得拉邦北部沿海维萨卡帕特南地区智障人群的酸性磷酸酶位点1 (ACP1)、酯酶D (ESD)、乙醛化酶位点1 (GLO1)、超氧化物歧化酶(SOD)和血红蛋白(HB) 5种红细胞遗传标记以及触珠蛋白(HP)、铜蓝蛋白(CP)、群体特异性成分(GC)、转铁蛋白(TF)和白蛋白(ALB) 5种血浆蛋白。结果与对照组的数据进行了比较。在研究的10个遗传标记中,ACP1和HP两个标记在患者和对照组之间存在显著差异。风险估计也显示出了显著的关联。
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