Genetic polymorphisms of t‐PA and PAI‐1 genes in the Korean population

Abstract

Abnormalities in fibrinolysis system is associated with risk of hypertension. In this report, the Alu repeat insertion/deletion (I/D) polymorphism of tissue plasminogen activator (t‐PA) and the Hind III RFLP of plasminogen activator inhibitor‐1 (PAI‐1) genes were investigated in 115 normotensives and 83 patients with hypertension, and their association with anthropometrical data and plasma biochemical parameters were analyzed. There were no significant differences in the gene frequencies of the two candidate genes between normotensives and hypertensives, respectively. Our results indicate lack of associations between the two polymorphisms in t‐PA and PAI‐1 genes and risk of hypertension in the population under study. However, the Hind III RFLP of PAI‐1 gene was significantly associated with plasma glucose level, suggesting its role in glucose metabolism. It needs to be tested whether this RFLP of PAI‐1 gene is associated with insulin resistance syndrome or non‐insulin dependent diabetes mellitus (NIDDM) in the Korean population.