Genetic links among individuals: from genealogies to molecular markers

C. Carré, F. Gamboa, B. Pujol, E. Manfredi
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引用次数: 3

Abstract

Abstract Genetic links among individuals are widely used to characterize the diversity of domesticated and natural populations and they also provide complementary information for statistical population summaries. We first discuss the measures used by geneticists based on genealogy and DNA data. The choice of metrics of genetic links should be coherent with the objectives: biodiversity or genotype–phenotype relationships. For the last objective, we evaluate by simulation the interest of genetic distances when the objective is the prediction of individual genetic values and phenotypes using kernel regression. A pseudo-distance based on correlations between marker genotypes of pairs of individual yields better predictions than other classical definition of distances.
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个体间的遗传联系:从家谱到分子标记
摘要个体间的遗传联系被广泛用于表征驯化种群和自然种群的多样性,并为种群统计总结提供补充信息。我们首先讨论了基于家谱和DNA数据的遗传学家使用的措施。遗传联系度量的选择应与目标一致:生物多样性或基因型-表型关系。对于最后一个目标,当目标是使用核回归预测个体遗传值和表型时,我们通过模拟评估遗传距离的兴趣。基于个体对的标记基因型之间的相关性的伪距离比其他经典的距离定义产生更好的预测。
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