Role of natural juice in improving the ventilatory functions of smokers with chronic obstructive pulmonary disease

Abstract

Purpose. Chronic obstructive pulmonary disease (COPD) is a common disease related to smoking. Oxidative stress and antioxidant status may play an important role in the pathogenesis of COPD. The aims of the present study were to determine the pathogenic effects of oxidative stress and antioxidant status in COPD smokers, and the role of dietary antioxidant supplementation in the ventilatory function tests (VFT) of the COPD smokers.Design. This study comprised two phases. The first phase explored oxidative stress and antioxidant status and its relationship with the ventilatory functions of COPD diagnosed smokers. The second phase was a self‐controlled clinical trial to study the changes in the oxidative–antioxidant status and the VFT of the COPD smoking patients after dietary supplementation with freshly prepared juice for 30 days.Methods. Personal, occupational and medical questionnaires, a clinical examination, VFT, serum antioxidants (vitamin A, C and E and β‐carotene), malondialdehyde (MDA) and superoxid...