From hacking the human genome to editing organs

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Organogenesis Pub Date : 2015-10-02 DOI:10.1080/15476278.2015.1120047

Takamasa Tobita, J. Guzman‐Lepe, Alexandra Collin de l'Hortet

引用次数: 5

Abstract

ABSTRACT In the recent decades, human genome engineering has been one of the major interesting research subjects, essentially because it raises new possibilities for personalized medicine and biotechnologies. With the development of engineered nucleases such as the Zinc Finger Nucleases (ZFNs), the Transcription activator-like effector nucleases (TALENs) and more recently the Clustered Regularly Interspaced short Palindromic Repeats (CRISPR), the field of human genome edition has evolved very rapidly. Every new genetic tool is broadening the scope of applications on human tissues, even before we can completely master each of these tools. In this review, we will present the recent advances regarding human genome edition tools, we will discuss the numerous implications they have in research and medicine, and we will mention the limits and concerns about such technologies

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从破解人类基因组到编辑器官

近几十年来，人类基因组工程一直是一个重要的有趣的研究课题，主要是因为它为个性化医疗和生物技术提供了新的可能性。随着工程核酸酶如锌指核酸酶(ZFNs)、转录激活因子样效应核酸酶(TALENs)和最近的聚集规则间隔短回语重复序列(CRISPR)的发展，人类基因组编辑领域发展非常迅速。每一种新的基因工具都在扩大人类组织的应用范围，甚至在我们完全掌握这些工具之前。在这篇综述中，我们将介绍关于人类基因组编辑工具的最新进展，我们将讨论它们在研究和医学中的众多影响，我们将提到这些技术的限制和关注

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.