Hoai Thi Nguyen, Duc Viet Ho, Hung Quoc Vo, Trang Huyen Xuan Hoang, T. Kodama, Takuya Ito, H. Morita, A. Raal
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引用次数: 3
Abstract
Abstract Sixteen compounds were isolated from the aerial parts of Sarcosperma affinis Gagnep. including (E)-phytol (1), heptadecan-1-ol (2), lupeol (3), oleanolic acid (4), 3β-hexadecanoyloleanolic acid (5), pomolic acid (6), euscaphic acid (7), myrianthic acid (8), (+)-pinoresinol (9), (+)-medioresinol (10), (+)-syringaresinol (11), quercetin-3-O-β-D-galactopyranoside (12), epicatechin (13), bis-(2-ethylhexyl) phthalate (14), 3-prenyl-4-O-β-D-glucopyranosyloxy-4-hydroxylbenzoic acid (15), icariside E5 (16). Their structures were elucidated by the combination of spectroscopy including 1D, 2D NMR, HR-ESI-MS and in comparison with the reported NMR data in the literature. Among those, compounds 4 and 6 showed potent antibacterial activity against Mycobacterium smegmatis with MIC values of 5.48 and 2.65 μM, respectively. The chemical composition and biological activity of constituents isolated from aerial parts of S. affinis was studied for the first time.
摘要:从附肉属植物(Sarcosperma affinis Gagnep)地上部分离得到16个化合物。包括(E)-叶绿醇(1)、十六烷醇(2)、鹿皮醇(3)、齐墩果酸(4)、3β-十六烷醇齐墩果酸(5)、果酸(6)、癸酸(7)、肉豆酸(8)、(+)-松脂醇(9)、(+)-中松脂醇(10)、(+)-丁香松脂醇(11)、槲皮素-3- o -β- d -半乳糖吡喃苷(12)、表儿茶素(13)、双-(2-乙基己基)邻苯二甲酸酯(14)、3-丙烯基-4- o -β- d -葡萄糖吡喃氧基-4-羟基苯甲酸(15)、icariside E5(16)。结合一维、二维NMR、HR-ESI-MS等波谱分析，并与文献报道的NMR数据进行比较，对其结构进行了鉴定。其中化合物4和6对耻垢分枝杆菌具有较强的抗菌活性，其MIC值分别为5.48 μM和2.65 μM。本文首次对从樟子树地上部分分离得到的化学成分和生物活性进行了研究。
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