Non-clinical toxicity study of the oil-resin and vaginal cream of Copaiba (Copaifera duckei, Dwyer)

Clarissa Silva Lima, Uriel David de Almeida e Silva, Larissa Daniele Machado Góes, Beatriz Martins de Sá Hyacienth, Helison de Oliveria Carvalho, Caio Pinho Fernandes, Andrés Navarrete Castro, J. C. Tavares Carvalho
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引用次数: 3

Abstract

Abstract The toxic effects of copaíba oil-resin (ORC) and the copaiba oil-resin vaginal cream (CVC) were evaluated in subacute treatment phase, in wistar rats, which were treated orally (p.o) and intravaginal (ivag). Treated groups received the dose of, 0.04 mg/kg, 28 mg/kg, and 32 mg/kg, respectively, with ORC (p.o), Copaifera duckei oil-resin (ORCV-ivag) and vaginal cream with oil-resin C. duckei (CVC – ivag). The treatment for 22 days with ORC and CVC did not cause clinical signs of toxicity, no deaths have been reported, and did not change the development weight of the animals. The females treated with ORC (p.o), exhibited greater intake of water, but the feed intake was not different in males and females. The use of CVC did not change the water intake of females, but altered feed intake. The ORCV was capable of causing hypoglycemic effect and elevated serum creatinine levels. The hematology parameters of the animals were not changed by ORC (p.o, 32 mg/kg). The use of CVC changed hematocrit, lymphocytes, and the concentration of hemoglobin. The use of CVC and ORCV (ivag), did not altered the biochemicals parameters. Females treated with ORC (p.o, 32 mg/kg) showed some kind of susceptibility to specific use (elevation of total cholesterol, HDL and alkaline phosphatase). The elevation of serum ALT and AST enzymes was not attributed to the use of ORC orally and intravaginal and the use of CVC, as well as the product of its formulation (BVC). The subacute treatment with C. duckei oil-resin and cream (CVC) did not cause clinical signs of toxicity, no deaths have been reported and did not change significantly the parameters evaluated in this study.
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Copaiba (Copaifera duckei, Dwyer)油树脂及阴道乳膏的非临床毒性研究
研究了copaíba油树脂(ORC)和copaiba油树脂阴道乳膏(CVC)在亚急性治疗期对wistar大鼠口服(p.o)和阴道内(ivag)的毒性作用。治疗组分别以0.04 mg/kg、28 mg/kg、32 mg/kg的剂量分别给予ORC (p.o)、duckei油树脂(ORCV-ivag)和duckei油树脂阴道乳膏(CVC -ivag)。用ORC和CVC治疗22天,没有引起临床毒性症状,没有死亡的报道,也没有改变动物的发育体重。经ORC (p.o)处理的雌鱼对水的摄取量较大,但雌鱼对饲料的摄取量差异不大。CVC的使用没有改变雌鱼的摄水量,但改变了采食量。ORCV能够引起降糖作用和血清肌酐水平升高。ORC (p.o, 32 mg/kg)对动物血液学参数无影响。CVC的使用改变了红细胞压积、淋巴细胞和血红蛋白的浓度。CVC和ORCV (ivag)的使用没有改变生化参数。用ORC (p.o, 32 mg/kg)处理的雌性对特定使用表现出一定的敏感性(总胆固醇、高密度脂蛋白和碱性磷酸酶升高)。血清ALT和AST的升高与口服和阴道内使用ORC和使用CVC及其制剂产品(BVC)无关。在亚急性治疗中,杜氏油树脂乳膏(CVC)未引起临床毒性症状,无死亡报告,本研究中评估的参数未发生显著变化。
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Cogent Biology
Cogent Biology MULTIDISCIPLINARY SCIENCES-
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