Circadian variation of serum leptin and adipose tissue changes in children

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2022-09-25 DOI:10.1111/ijpo.12984

Anna Zenno, Sheila M. Brady, Loie M. Faulkner, Kaitlin L. Ballenger, Syeda Fatima, Jack A. Yanovski

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Abstract

Background

Higher morning serum leptin values are associated with larger adipose tissue gains in children; however, it is unclear if leptin circadian variation is itself associated with adipose tissue changes during growth.

Objective

We studied the association of circadian variation in leptin with change in total body fat mass (TBFM), total body percentage fat (%FM), and trunk fat mass (TrFM).

Methods

Baseline serum samples for leptin were obtained every 3 h for 24 h from 130 children (baseline age 9.6 ± 2.5y; 51.1% male; BMI-Z 1.59) with mean follow-up of 11.1 ± 4.0y and underwent dual-energy x-ray absorptiometry. ANCOVA models examined change in TBFM, %FM, or TrFM as dependent variables and number of years of follow-up, sex, race, baseline age, pubertal status, initial visit body composition, and initial visit serum leptin circadian variables (maximal diurnal leptin [acrophase], diurnal amplitude, and percentage change of amplitude) as independent factors.

Result

Although initial visit mesor (24 h average) leptin was positively associated with initial visit TBFM (r² = 0.78, p < 0.001), %FM (r² = 076, p < 0.001), and TrFM (r² = 0.71, p < 0.001), none of the circadian leptin variables studied was significantly associated with change in TBFM, %FM, or TrFM.

Conclusion

We found no evidence that circadian variation in serum leptin concentrations during childhood is associated with long-term changes in children's adiposity.

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儿童血清瘦素和脂肪组织变化的昼夜变化

背景:儿童早晨血清瘦素值越高，脂肪组织增加越大;然而，目前尚不清楚瘦素昼夜变化本身是否与生长过程中脂肪组织的变化有关。目的研究瘦素昼夜变化与全身脂肪质量(TBFM)、全身脂肪百分比(%FM)和躯干脂肪质量(TrFM)变化的关系。方法对130例儿童(基线年龄9.6±2.5岁;男性51.1%;BMI-Z 1.59)，平均随访11.1±4.0y，行双能x线吸收测定。ANCOVA模型检验了TBFM、%FM或TrFM作为自变量的变化，以及随访年数、性别、种族、基线年龄、青春期状态、初诊体成分和初诊血清瘦素昼夜变量(最大日瘦素[高峰期]、日幅度和幅度变化百分比)作为独立因素的变化。结果虽然初诊时间(平均24小时)瘦素与初诊TBFM (r2 = 0.78, p < 0.001)、%FM (r2 = 076, p < 0.001)和TrFM (r2 = 0.71, p < 0.001)呈正相关，但所研究的昼夜节律瘦素变量与TBFM、%FM或TrFM的变化均无显著相关性。结论:我们没有发现儿童时期血清瘦素浓度的昼夜变化与儿童肥胖的长期变化相关的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.