A Comparison of the Hemostatic Effects of Notoginseng and Yun Nan Bai Yao to Placebo Control

Abstract

Introduction: We previously demonstrated the hemostatic effects of notoginseng using a rat bleeding model. Yun Nan Bai Yao is a proprietary product for external use in China to treat bleeding but the hemostatic effects have not been proven. This study was conducted to compare the hemostatic effects of notoginseng to that of Yun Nan Bai Yao and placebo control. Methods: Rats (n = 37) were randomized into 3 groups and their tails were transected 5 mm from the tip in this blinded investigation. Group 1 received placebo (wheat flour, n = 17), group 2 received notoginseng (n = 10) and group 3 received the Yun Nan Bai Yao (n = 10). The total bleeding time was determined and compared among groups. Results: Bleeding time in minutes was 29.7% and 22.3% lower in the notoginseng and Yun Nan Bai Yao groups than the placebo group (p < 0.001 and p < 0.001, respectively). No significant difference was found between the two active groups (p = 0.418). Conclusions: When applied externally, both notoginseng and Yun Nan Bai Yao pro.