Evaluation of Antidiabetic Activity of Coldenia procumbens in Alloxan-Induced Diabetes in Rat

Abstract

Diabetes was induced in Groups II, III and IV rats by alloxan monohydrate at the rate of 180 mg/kg body weight. Body weight increased significantly (p < 0.05) after Coldenia procumbens treatment. Treatment with C. procumbens significantly (p < 0.05) reduced the blood glucose level from 394.17 ±10.52 (mg/dl) to 152.83 ±2.15 (mg/ dl) in rats when compared with diabetic control group of rats. Serum triglyceride levels decreased significantly (p < 0.05) from 152.33 ±2.75 (mg/dl) to 109.17 ±1.74 (mg/dl) in C. procumbens-treated rats. Treatment with C. procumbens significantly (p < 0.05) reduced the serumcholesterol level from 59.83 ±1.01 (mg/dl) to 44.33 ±1.96 (mg/dl) in rats. The analysis of data indicates that the test drug has good hypoglycemic effect in diabetic rats.