{"title":"Effect of acute morphine administration on the metabolism of brain catecholamines.","authors":"H. Loh, R. Hitzemann, E. Way","doi":"10.1097/00132586-197402000-00015","DOIUrl":null,"url":null,"abstract":"Abstract The effects of sub-analgetic and analgetic doses of morphine (5–20 mg/kg) on the metabolism of intravenously administered [ 14 C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [ 14 C]-tyrosine to the [ 14 C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [ 14 C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.","PeriodicalId":78415,"journal":{"name":"Life sciences. Pt. 1: Physiology and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1973-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00132586-197402000-00015","citationCount":"35","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life sciences. Pt. 1: Physiology and pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00132586-197402000-00015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 35
Abstract
Abstract The effects of sub-analgetic and analgetic doses of morphine (5–20 mg/kg) on the metabolism of intravenously administered [ 14 C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [ 14 C]-tyrosine to the [ 14 C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [ 14 C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.
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