Phages Form Liquid Crystals, Shaping P. aeruginosa Biofilms

Shannon Weiman
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Abstract

Through a novel mechanism, bacteriophage particles link with the surfaces of Pseudomonas aeruginosa cells and other nearby polymers to form tenacious biofilms, including those that form within the lungs of cystic fibrosis (CF) patients, according to Paul Bollyky of Stanford University in Stanford, Calif., who spoke during the Bay Area Microbial Pathogenesis Symposium last March in San Francisco. Bacteriophage that reproduce within P. aeruginosa are released and can assemble into liquid crystal structures that surround and protect these bacteria as part of larger biofilms, according to Bollyky, Patrick Secor, William Parks, and their collaborators. Details describing some of this research appeared November 11, 2015 in Cell Host & Microbe (doi:http://dx.doi.org/10.1016/j.chom.2015.10.013).
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噬菌体形成液晶,形成铜绿假单胞菌生物膜
根据加州斯坦福大学的Paul Bollyky在去年3月旧金山海湾地区微生物发病机制研讨会上的发言,通过一种新的机制,噬菌体颗粒与铜绿假单胞菌细胞和其他附近聚合物的表面连接,形成坚韧的生物膜,包括在囊性纤维化(CF)患者的肺内形成的生物膜。根据Bollyky、Patrick Secor、William Parks和他们的合作者的说法,在铜绿假单胞菌体内繁殖的噬菌体被释放出来,并可以组装成液晶结构,包围并保护这些细菌,作为更大生物膜的一部分。2015年11月11日,《细胞宿主与微生物》(doi:http://dx.doi.org/10.1016/j.chom.2015.10.013)上发表了一些描述这项研究的细节。
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