Microbes as Intein Havens: These microbial, intron-like polypeptides are self-splicing elements that remove themselves posttranslationally from their host proteins
{"title":"Microbes as Intein Havens: These microbial, intron-like polypeptides are self-splicing elements that remove themselves posttranslationally from their host proteins","authors":"Cathleen M. Green, M. Belfort","doi":"10.1128/MICROBE.11.388.1","DOIUrl":null,"url":null,"abstract":"Inteins are polypeptide escape artists, with an extraordinary ability to excise themselves from fully folded proteins without leaving a trace. Inteins are best described as protein introns, self-splicing elements that remove themselves posttranslationally from their host proteins. They occur in all three domains of life—archaea, bacteria, and single-celled eukaryotes (Fig. 1A). Even so, inteins are rarely discussed among microbiologists, but this relative silence is about to be broken.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbe (Washington, D.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/MICROBE.11.388.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Inteins are polypeptide escape artists, with an extraordinary ability to excise themselves from fully folded proteins without leaving a trace. Inteins are best described as protein introns, self-splicing elements that remove themselves posttranslationally from their host proteins. They occur in all three domains of life—archaea, bacteria, and single-celled eukaryotes (Fig. 1A). Even so, inteins are rarely discussed among microbiologists, but this relative silence is about to be broken.