Zika Genome Sequences Set for Diagnostic, Vaccine Development Purposes

D. Holzman
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Abstract

Zika virus strains fall into two major genetic lineages—one African, the other Asian—based on recent genome sequencing analysis, according to Young-Min Lee of Utah State University, Logan, and his collaborators. “Studies are currently underway at Utah State University to examine the functional importance of the genetic variation on viral replication and pathogenesis,” he says. Meanwhile, the World Health Organization (WHO) designated another Zika isolate as a reference strain for use in diagnosis. Its sequence was determined by Sally Baylis of the Paul-Ehrlich-Institut in Langen, Germany, and her collaborators. Details appeared online in Genome Announcements, August 18 and September 1, 2016, respectively (doi:10.1128/genomeA.00917–16, and doi:10.1128/genomeA.00800–16).
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寨卡病毒基因组序列用于诊断和疫苗开发
根据犹他州立大学洛根分校的李永民(Young-Min Lee)和他的合作者的研究,根据最近的基因组测序分析,寨卡病毒毒株可分为两个主要的遗传谱系——一个是非洲的,另一个是亚洲的。他说:“犹他州立大学目前正在进行研究,以检查基因变异在病毒复制和发病机制中的功能重要性。”与此同时,世界卫生组织(WHO)指定了另一种寨卡病毒分离株作为诊断参考菌株。它的序列是由德国兰根paul - ehrlich研究所的Sally Baylis和她的合作者确定的。详情分别刊登在2016年8月18日和9月1日的Genome announcement (doi:10.1128/ Genome)上。doi:10.1128/genome .00800 - 16)。
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