Significance of epidermal growth factor receptor expression in the grading of phyllodes tumors of the breast

Yong-Han Jung, Won-Hwa Yoon, Hye-Kyoung Yoon
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引用次数: 1

Abstract

Background and aim: Limited studies on the relationships between epidermal growth factor receptor (EGFR) expression and the grades of phyllodes tumors (PT) of the breast were reported. This study evaluated the significance of EGFR overexpression in the grading of PT. Methods: Immunohistochemical stain for EGFR was done in 46 PT cases. The differences of EGFR expression according to the degrees of cytologic atypia and mitotic count and between benign, borderline and malignant PTs based on Rosen or World Health Organization (WHO) criteria were analyzed. Results: Significant differences of positive (moderate membranous and cytoplasmic, more than 10% of tumor cells) and strong positive (moderate more than 50% of tumor cells) reactions for EGFR were found according to the degree of cytologic atypia (P= 0.0016 and P= 0.0122) and between the PTs showing ≤5 mitoses and >5 mitoses/10 high power field (P= 0.0230 and P= 0.0058). Positive reaction for EGFR was more common in borderline/malignant PTs than benign PTs, and strong positive reaction for EGFR was relatively common in malignant PTs. Conclusions: Epidermal growth factor receptor overexpression, more than 10% of tumor cells, could be used as an ancillary tool for the discrimination of benign from borderline and malignant PTs.

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表皮生长因子受体表达在乳腺叶状肿瘤分级中的意义
背景与目的:关于乳腺叶状瘤(PT)分级与表皮生长因子受体(EGFR)表达关系的研究报道较少。方法:对46例PT患者行EGFR免疫组化染色。根据细胞异型性程度和有丝分裂计数,以及基于Rosen或WHO标准的良性、交界性和恶性PTs,分析EGFR表达的差异。结果:EGFR阳性反应(中度膜质性和细胞质性,大于10%的肿瘤细胞)和强阳性反应(中度大于50%的肿瘤细胞)在细胞学异型程度上有显著差异(P= 0.0016和P= 0.0122),在有丝分裂≤5个和有丝分裂>5个/10个高倍视场的PTs之间有显著差异(P= 0.0230和P= 0.0058)。EGFR阳性反应在交界性/恶性PTs中较良性PTs多见,EGFR强阳性反应在恶性PTs中较为常见。结论:表皮生长因子受体过表达(占肿瘤细胞的10%以上)可作为鉴别PTs良、交界性和恶性的辅助工具。
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