Morphological MRI investigations of the hypothalamus in 232 individuals with Parkinson's disease

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2019-08-21 DOI:10.1002/mds.27814

Martin Gorges PhD, Barbara Kuntz MS, Kelly Del Tredici MD, PhD, Daniel G. Schmidt MSc, Hans-Peter Müller PhD, Albert C. Ludolph MD, Luc Dupuis PhD, Jan Kassubek MD

{"title":"Morphological MRI investigations of the hypothalamus in 232 individuals with Parkinson's disease","authors":"Martin Gorges PhD, Barbara Kuntz MS, Kelly Del Tredici MD, PhD, Daniel G. Schmidt MSc, Hans-Peter Müller PhD, Albert C. Ludolph MD, Luc Dupuis PhD, Jan Kassubek MD","doi":"10.1002/mds.27814","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>High-resolution T<sub>1</sub>-weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, <i>V</i> = 921 ± 78 mm<sup>3</sup> vs 30 non-PD, <i>V</i> = 917 ± 67 mm<sup>3</sup>; <i>P</i> = 0.850) and validated in a large cohort (202 PD, <i>V</i> = 925 ± 88 mm<sup>3</sup> vs 100 non-PD, <i>V</i> = 932 ± 114 mm<sup>3</sup>; <i>P</i> = 0.602).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p>\n </section>\n </div>","PeriodicalId":213,"journal":{"name":"Movement Disorders","volume":null,"pages":null},"PeriodicalIF":7.4000,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds.27814","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mds.27814","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 8

Abstract

Background

The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.

Methods

High-resolution T₁-weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.

Results

The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, V = 921 ± 78 mm³ vs 30 non-PD, V = 917 ± 67 mm³; P = 0.850) and validated in a large cohort (202 PD, V = 925 ± 88 mm³ vs 100 non-PD, V = 932 ± 114 mm³; P = 0.602).

Conclusions

Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

232例帕金森病患者下丘脑的形态学MRI研究

背景下丘脑参与帕金森病(PD)的病理生理机制尚不清楚。本研究的目的是量化PD患者体内下丘脑体积。方法采用高分辨率t1加权磁共振成像(MRI)数据对232例PD患者和130例健康非PD患者下丘脑体积进行定量分析。结果在前瞻性收集的亚队列中，体积分析显示PD患者的下丘脑没有萎缩(30名PD患者，V = 921±78 mm3 vs 30名非PD患者，V = 917±67 mm3;P = 0.850)，并在大型队列中得到验证(202名PD患者，V = 925±88 mm3 vs 100名非PD患者，V = 932±114 mm3;p = 0.602)。大量的组织病理学证据表明，PD患者的下丘脑受累似乎无法通过基于mri的体积量化检测到。©2019作者。Wiley期刊公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.