SPOCK1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Head and Neck Squamous Cell Carcinoma

Ying Liu, Linyuan Feng, Yang Yang, Zhenhua Lin, Wen-zheng Jiang
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Abstract

Background: To explore expression and immune infiltration of SPARC/osteonectin, cwcv, and maze-like domains proteoglycan 1 (SPOCK1) in Head and Neck squamous cell carcinoma. Methods: A total of 107 HNSC patients’ tissues and 15 adjacent normal tissues were collected in this study. Co-expressed gene and gene set enrichment analysis was detected using STRING and Linked Omics. Immune cell infiltration related to SPOCK1 was analyzed via TIMER. Results: The positive rate of SPOCK1 in HNSC tissues were significantly higher than that in normal tissues by immunohistochemical staining (p< 0.01). The expression of SPOCK1 in HNSC was a positive correlation with the level of immune infiltrating cells. In addition, we discovered that SPOCK1 was major involved in inflammatory response pathways, cancer cell proliferation regulation, cell cycle regulation, apoptosis, adhesion, cell-matrix interaction, etc. Conclusions: SPOCK1 plays a role in promoting cancer in HNSC, which was closely related to the malignant evolution of HNSC, and it was expected to become a prognostic molecular marker for HNSC patients and a potential target for immunotherapy.
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SPOCK1是一种预后相关的生物标志物,与头颈部鳞状细胞癌的免疫浸润相关
背景:探讨SPARC/骨连接素、cwcv和迷宫样结构域蛋白多糖1 (SPOCK1)在头颈部鳞状细胞癌中的表达和免疫浸润。方法:本研究共收集HNSC患者组织107例,周围正常组织15例。使用STRING和Linked组学检测共表达基因和基因集富集分析。通过TIMER分析SPOCK1相关的免疫细胞浸润。结果:经免疫组化染色,SPOCK1在HNSC组织中的阳性率明显高于正常组织(p< 0.01)。SPOCK1在HNSC中的表达与免疫浸润细胞水平呈正相关。此外,我们发现SPOCK1主要参与炎症反应通路、癌细胞增殖调节、细胞周期调节、凋亡、粘附、细胞-基质相互作用等。结论:SPOCK1在HNSC中具有促癌作用,与HNSC的恶性发展密切相关,有望成为HNSC患者预后的分子标志物和免疫治疗的潜在靶点。
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