A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease

Q1 Pharmacology, Toxicology and Pharmaceutics Advances in Pharmacological Sciences Pub Date : 2016-01-28 DOI:10.1155/2016/8964849

A. Afshari, H. Sadeghnia, H. Mollazadeh

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引用次数: 83

Abstract

The current management of Alzheimer's disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T. chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid. This review shows that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer's disease.

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脑末梢在阿尔茨海默病中的潜在机制研究进展

目前阿尔茨海默病(AD)的治疗主要集中在乙酰胆碱酯酶抑制剂(AChEIs)和NMDA受体拮抗剂上，尽管结果并不完全有利。因此，在草药植物中发现的新药物作为可能的治疗替代品正在引起人们的注意。chebula (combreaceae科)是一种具有广泛药用特性的药用植物，据报道含有多种生物化学物质，如水解单宁、酚类化合物和类黄酮，因此它可能是一种很好的治疗选择。在本研究中，我们查阅了PubMed、Science Direct、Scopus、Web of Science、Scirus和谷歌Scholar等数据库中已发表的科学文献，关键词:T. chebula, AD，神经保护，药用植物，抗氧化剂，鞣花丹宁，没食子酸，没食子酸，chebulagic acid, chebulic acid。这篇综述表明，雪桐提取物及其成分具有乙酰胆碱酯酶(AChEI)和抗氧化、抗炎作用，这些作用目前都与阿尔茨海默病的治疗有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Pharmacological Sciences PHARMACOLOGY & PHARMACY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Advances in Pharmacological and Pharmaceutical Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of experimental and clinical pharmacology, pharmaceutics, medicinal chemistry and drug delivery. Topics covered by the journal include, but are not limited to: -Biochemical pharmacology, drug mechanism of action, pharmacodynamics, pharmacogenetics, pharmacokinetics, and toxicology. -The design and preparation of new drugs, and their safety and efficacy in humans, including descriptions of drug dosage forms. -All areas of medicinal chemistry, such as drug discovery, design and synthesis. -Basic biology of drug and gene delivery through to application and development of these principles, through therapeutic delivery and targeting. Areas covered include bioavailability, controlled release, microcapsules, novel drug delivery systems, personalized drug delivery, and techniques for passing biological barriers.