{"title":"Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes","authors":"M. Lefranc","doi":"10.1159/000049189","DOIUrl":null,"url":null,"abstract":"‘Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes’, the 16th report of the ‘IMGT Locus in Focus’ section, provides the first complete list of all the human IGH genes. The total number of human IGH genes per haploid genome is 170–176 (206–212 genes, if the orphons and the processed gene are included), of which 77–84 genes are functional. IMGT/Human Genome Organization (HUGO) gene names and definitions of the human IGH genes on chromosome 14q32.33, processed gene on chromosome 9 and IGH orphons on chromosomes 15 and 16 are provided with the gene functionality and the number of alleles, according to the rules of the IMGT Scientific chart, with the accession numbers of the IMGT reference sequences and with the accession ID of the Genome Database GDB and NCBI LocusLink databases, in which all the IMGT human IGH genes have been entered. The tables are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.","PeriodicalId":77124,"journal":{"name":"Experimental and clinical immunogenetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000049189","citationCount":"91","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical immunogenetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000049189","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 91
Abstract
‘Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes’, the 16th report of the ‘IMGT Locus in Focus’ section, provides the first complete list of all the human IGH genes. The total number of human IGH genes per haploid genome is 170–176 (206–212 genes, if the orphons and the processed gene are included), of which 77–84 genes are functional. IMGT/Human Genome Organization (HUGO) gene names and definitions of the human IGH genes on chromosome 14q32.33, processed gene on chromosome 9 and IGH orphons on chromosomes 15 and 16 are provided with the gene functionality and the number of alleles, according to the rules of the IMGT Scientific chart, with the accession numbers of the IMGT reference sequences and with the accession ID of the Genome Database GDB and NCBI LocusLink databases, in which all the IMGT human IGH genes have been entered. The tables are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.
《Human Immunoglobulin Heavy (IGH) Genes的命名法》是“IMGT Locus in Focus”部分的第16篇报道,首次提供了所有人类IGH基因的完整列表。每个单倍体基因组的人类IGH基因总数为170-176个(如果包括孤儿和加工基因,则为206-212个),其中77-84个基因是功能性的。IMGT/Human Genome Organization (HUGO)人类染色体14q32.33上的IGH基因、第9号染色体上的加工基因、第15号和第16号染色体上的IGH孤儿的基因名称和定义,根据IMGT科学图谱的规则,提供基因功能和等位基因数量,并提供IMGT参考序列的加入号,以及基因组数据库GDB和NCBI LocusLink数据库的加入ID。其中所有的IMGT人类IGH基因都已进入。这些表格可在国际免疫遗传学数据库IMGT的IMGT Marie-Paule页面(http://imgt.cines.fr:8104)上获得,该数据库由法国蒙彼利埃第二大学的Marie-Paule Lefranc创建。