The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.

IF 2.5 3区生物学 Q3 GENETICS & HEREDITY Hereditas Pub Date : 2015-10-22 eCollection Date: 2015-01-01 DOI:10.1186/s41065-015-0004-7

David Ruiz-Ramos, Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Juárez-Rojop, María Lilia López-Narváez, Thelma Beatriz González-Castro, Manuel Eduardo Torres-Hernández, Manuel Alfonso Baños-González

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Abstract

Background: Genetic factors play an important role in the pathogenesis of coronary heart disease (CHD). Kinesin-like protein 6 (KIF6) is a new candidate gene for CHD, since it has been identified as a potential risk factor. The aim of this study was to perform a systematic review and meta-analysis of previously published association studies between the Trp719Arg polymorphism of KIF6 and the development of CHD.

Methods: Studies and abstracts investigating the relationship between the Trp719Arg polymorphism of KIF6 and subsequent risk for development of CHD were reviewed. Electronic search from Pubmed and EBSCO databases was performed between 1993 and 2014 to identify studies that fulfilled the inclusion criteria. To analyze the association we used the models: allelic, additive, dominant and recessive. Moreover, we conducted a sub-analysis by populations using the same four models.

Results: Twenty-three studies were included in the meta-analysis. The Trp719Arg polymorphism showed a significant association with CHD when the analysis comprised the population with myocardial infarction (MI) and the additive genetic model was used. Moreover, this polymorphism showed a protective association with CHD when the analysis comprised the whole population using the recessive genetic model.

Conclusions: Our findings indicate that the Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing MI and that allele 719Arg may have a protective association to present CHD in all populations.

Prospero registration: CRD42015024602.

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KIF6基因Trp719Arg多态性与冠心病风险：系统回顾和荟萃分析

背景：遗传因素在冠心病的发病机制中起重要作用。运动蛋白样蛋白6 （KIF6）是一个新的候选基因，因为它已被确定为冠心病的潜在危险因素。本研究的目的是对先前发表的KIF6 Trp719Arg多态性与冠心病发展之间的关联研究进行系统回顾和荟萃分析。方法：回顾研究KIF6基因Trp719Arg多态性与冠心病发病风险关系的研究和摘要。在1993年至2014年间从Pubmed和EBSCO数据库中进行电子检索，以确定符合纳入标准的研究。采用等位基因、加性基因、显性基因和隐性基因模型进行分析。此外，我们使用相同的四种模型进行了种群的亚分析。结果：23项研究被纳入meta分析。当分析包括心肌梗死（MI）人群并使用加性遗传模型时，Trp719Arg多态性显示与冠心病有显著关联。此外，当使用隐性遗传模型对整个人群进行分析时，这种多态性显示出与冠心病的保护性关联。结论：我们的研究结果表明，KIF6基因的Trp719Arg多态性是发生心肌梗死的重要危险因素，等位基因719Arg可能与所有人群中出现的冠心病有保护作用。普洛斯彼罗注册号：CRD42015024602。

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来源期刊

Hereditas 生物-遗传学

CiteScore

4.30

自引率

3.70%

发文量

审稿时长

6 weeks

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.