Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging

Abstract

Breast cancer(BC)is one of the most common diseases in women. The accurate detection for BC is very important in clinical practice. In this paper,in-vivo breast cancer in a subcutaneous xe‐ nograft mouse was studied with the continuous-wave terahertz(THz) reflection imaging system at 2. 52THz. The high reflection region in THz images of in-vivo subcutaneous xenograft mouse corre‐ sponded well to the tumor area in visible. The difference value of 15% between tumor and normal tis‐ sues was observed. For the gold standard,the tumor areas at different depths from the surface of skin 文章编号:1001-9014(2020)05-0553-08 DOI:10. 11972/j. issn. 1001-9014. 2020. 05. 004 收稿日期:2019⁃ 09⁃ 26,修回日期:2020⁃ 06⁃ 04 Received date:2019⁃ 09⁃ 26,Revised date:2020⁃ 06⁃ 04 基金项目:国家 973计划(2015CB755403),国家自然科学基金(61775160,61771332),中国博士后科学基金特别资助(2016M602954),重庆市 博士后科研项目特别资助(Xm2016021),重庆西南医院生物强院科技创新计划(SWH2016LHJC04,SWH2016LHJC01) Foundation items:Supported by National Basic Research Program of China(973)(2015CB755403),National Natural Science Foundation of China (NSFC)(61775160,61771332),China Postdoctoral Science Foundation(2016M602954),Postdoctoral Science Foundation of Chongqing (Xm2016021),Joint Incubation Project of Southwest Hospital(SWH2016LHJC-04,SWH2016LHJC-01); 作者简介(Biography):武丽敏(1989-),女,山东聊城人,博士生,主要研究领域为太赫兹生物医学成像 . E-mail:wulimin@tju. edu. cn. *通讯作者(Corresponding author):E-mail:yuyewang@tju. edu. cn