Ethological studies in Swiss albino mice with special reference to the histology of the cerebellar tissue after an acute as well as a continuous low-dose tritiated water (HTO) exposure

N. Jain
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Abstract

Health and environmental impact of tritium released from fusion reactor technology may end up as a worldwide problem in the final analysis. Pregnant Swiss albino mice were irradiated with 11.1 kBq ml–1 tritiated drinking water. The young ones born to them were maintained on tritiated water (HTO) at the same dose level and in adulthood, when tested in a maze showed an apparent increased learned behaviour over the controls, though statistically not significant. Similar results have been obtained when mice were acutely irradiated at a dose 185 kBq gm–1 body weight of tritiated water. Histologically, in the cerebellar tissue excised from mice brain after the ethology experiments, there was a depopulation of granule cells and the Purkinje cells appeared pyknotic and shrunken at certain places. At the cellular level, definitely there are radiopathological changes in brain, however, very contrastingly, at the organism level ethological data show a better learned behaviour in mice post tritiated water exposure.
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瑞士白化病小鼠的行为学研究,特别涉及急性和连续低剂量氚化水(HTO)暴露后小脑组织的组织学
核聚变反应堆技术释放的氚对健康和环境的影响最终可能成为一个世界性的问题。用11.1 kBq ml-1的氚化饮用水照射怀孕的瑞士白化小鼠。他们所生的幼崽被维持在相同剂量的氚化水(HTO)中,成年后,当在迷宫中进行测试时,表现出比对照组明显增加的学习行为,尽管统计上不显着。以185 kBq gm-1体重的氚水急性照射小鼠,也得到了类似的结果。行为学实验后切除的小鼠小脑组织中颗粒细胞数量减少,部分部位浦肯野细胞缩缩。在细胞水平上,大脑确实有放射病理变化,然而,与之相反的是,在生物体水平上,行为学数据显示,接触过氚化水的老鼠有更好的学习行为。
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International Journal of Low Radiation
International Journal of Low Radiation Environmental Science-Health, Toxicology and Mutagenesis
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期刊介绍: The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.
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