{"title":"Low-dose ionising radiation effects: effects of thoron inhalation","authors":"A. Menon, R. Indu, Tiju Chacko, C. Nair","doi":"10.1504/IJLR.2014.063409","DOIUrl":null,"url":null,"abstract":"Cellular DNA damage, tissue antioxidant levels, serum parameters, blood count and histopathological alterations were examined in tissues of mice exposed to thoron (average radiation dose0.065 μSv/hr). Alkaline cometassay results indicated that inhalation of thoron caused significant increase in the damage to DNA of lung tissue, while there was no significant damage to DNA in bone marrow cells. A small increase in cellular DNA damage was also seen in blood leukocytesfollowing thoron exposure. Inhalation of thoron induced severe damage in the lung cells leading to their elimination by apoptosis. Histology of lungs showed areas of abnormalities. An increase in the level of inflammatory response mediator, NF-κB, was also observed in the lung tissue of exposed mice. The DNA damage in lung cells could be induced by high energy radiation emanating from radioactive decay of thoron and its progeny particularly the alpha radiation of 8.88 MeV from 212Po.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"9 1","pages":"252"},"PeriodicalIF":0.0000,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063409","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Low Radiation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1504/IJLR.2014.063409","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 4
Abstract
Cellular DNA damage, tissue antioxidant levels, serum parameters, blood count and histopathological alterations were examined in tissues of mice exposed to thoron (average radiation dose0.065 μSv/hr). Alkaline cometassay results indicated that inhalation of thoron caused significant increase in the damage to DNA of lung tissue, while there was no significant damage to DNA in bone marrow cells. A small increase in cellular DNA damage was also seen in blood leukocytesfollowing thoron exposure. Inhalation of thoron induced severe damage in the lung cells leading to their elimination by apoptosis. Histology of lungs showed areas of abnormalities. An increase in the level of inflammatory response mediator, NF-κB, was also observed in the lung tissue of exposed mice. The DNA damage in lung cells could be induced by high energy radiation emanating from radioactive decay of thoron and its progeny particularly the alpha radiation of 8.88 MeV from 212Po.
期刊介绍:
The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.