Yury Gennadievich Baranovsky, E. Y. Shapovalova, Tatiana Boyko, I. A. Lugin, S. V. Harchenko, A. Baranovsky, A. Kubyshkin
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Abstract
The problem of healing long-term skin defects, complicated by venous insufficiency, remains a problem despite many known treatments. The article researches immunological compatibility and efficiency of the use of collagen sponges with skin allogeneic fibroblasts for stimulation of wound healing. Sixteen mature C57/B1 mice were divided into two equal groups: control and experimental. In the 10th-day dynamic, the stimulation method was found to be highly effective by associating the collagen sponge with the allofibroblasts, which allows a significant improvement in the morphological characteristics of the sample biopsy and does not cause an autoimmune response to the transplant
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