Expression profile and TNF-α gene polymorphism in primary open-angle glaucoma

Abstract

The TNF-α 308 G/A (rs1800629) gene polymorphism was studied in 56 patients with primary open-angle glaucoma (POAG), and TNF-α levels were determined in 103 lacrimal fluid samples. An increase in TNF-α – 94 [45; 165] pkg/ml in patients with glaucoma compared with the control group (p=0.001) was revealed. The probability of developing POAG increased in residents of the homozygous for the rare allele genotype 308 A/A – 6.30 (95 % CI: 0.77–51.9, p=0.049), as well as in the owners of the heterozygous genotype 308 G/A – 3.60 (95 % CI: 0.96–13.6, p=0.049). High levels of TNF-α in the lacrimal fluid in patients with POAG are associated with the A308A genotype –