The Role of Oncogenic Infectious Agents in Causing Liver, Stomach, Urinary Bladder, Head and Neck and Cervical Cancers

R. Shabrawy, A. Abdelateef, Ahmed Abdel Reheem Al Nagar, A. Salem
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Abstract

Background: Understanding the pathogenesis and predisposing factors for cancer is a major concern. Several studies have elucidated the role of infection in developing certain malignancies. Aim: The aim of this work was to assess the role of infectious agents in causing liver, stomach, urinary bladder, head and neck and cervical cancers. Methods: This case-control study included 181, diagnosis of several infectious agents included genetic and serological tests in both groups. The relative risk of each infectious agent was then calculated. Results: Oncogenic infectious agents cause 81.2% of studied cancers. HCV was detected in 92.2% of HCC with a relative risk of 4.6, HBV was detected in 5% of cases and relative risk of 4.8, H. pylori DNA was found in 77% of gastric cancer and a relative risk of 1.2 and S. heamatobium was found in 37.5% of urinary bladder cases with a relative risk of 31. Finally, HPV16 DNA was detected in 56.2% of head and neck cancer and 66.6% of cervical cancer with a relative risk of 3.12 and 3.7 respectively. Conclusion: Infections play an important role in the pathogenesis of cancer. Better attention to Infection prevention and control programs must be adapted to decrease the burden of malignant diseases.
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致瘤性感染因子在肝癌、胃癌、膀胱癌、头颈癌和子宫颈癌中的作用
背景:了解癌症的发病机制和易感因素是人们关注的主要问题。一些研究已经阐明了感染在发展某些恶性肿瘤中的作用。目的:本研究的目的是评估感染因子在引起肝癌、胃癌、膀胱癌、头颈癌和宫颈癌中的作用。方法:本研究纳入181例病例对照研究,两组患者均进行了遗传和血清学检测。然后计算每种传染因子的相对风险。结果:致瘤性感染因子导致了81.2%的癌症。HCV在92.2%的HCC中检出,相对危险度为4.6;HBV在5%的病例中检出,相对危险度为4.8;胃癌在77%的病例中检出幽门螺旋杆菌DNA,相对危险度为1.2;膀胱在37.5%的病例中检出血友病杆菌,相对危险度为31。头颈癌和宫颈癌的HPV16 DNA检出率分别为56.2%和66.6%,相对危险度分别为3.12和3.7。结论:感染在肿瘤的发病过程中起重要作用。必须加强对感染预防和控制规划的重视,以减轻恶性疾病的负担。
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